Donnatal

Donnatal

Donnatal is a proprietary combination medication for the treatment of intestinal cramping due to various causes, often administered as part of a GI Cocktail.[1] It is classed as an anticholinergic antispasmodic drug. Donnatal is marketed by PBM Pharmaceuticals. It is available as tablets, capsules, extended release tablets and elixir. Active ingredients are listed as: phenobarbital, hyoscyamine, atropine and scopolamine. The latter three ingredients being found in plants of the datura variety, a deliriant sometimes used recreationally, though the experience is often considered unpleasant.

Recent clinical trials showed that Donnatal was no more effective than plain antacid in relieving the symptoms of dyspepsia.[1][2] However, the active ingredients in Donnatal® have been shown to be more effective than placebo in treating moderately severe symptoms of irritable bowel syndrome.[3]

More information can be found at http://www.donnatal.com

References

  1. ^ a b Berman DA, Porter RS, Graber M (2003). "The GI Cocktail is no more effective than plain liquid antacid: a randomized, double blind clinical trial". J Emerg Med 25 (3): 239–44. doi:10.1016/S0736-4679(03)00196-3. PMID 14585449. 
  2. ^ Bowman J, Jones J (2006). "Use of lidocaine in the gastrointestinal cocktail for the treatment of dyspepsia". Emerg Med J 23 (11): 873–4. doi:10.1136/emj.2006.042168. PMC 2464394. PMID 17057145. http://emj.bmj.com/cgi/pmidlookup?view=long&pmid=17057145. 
  3. ^ Rhodes JB, Abrams JH, Manning RT (1978). "Controlled clinical trial of sedative-anticholinergic drugs in patients with the irritable bowel syndrome". J Clin Pharmacol 18 (7): 340–5. PMID 353089. 

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