HLA-A69

SerotypeA_normal
locus = A
type = 69
allelegroup = 69
dominant = 01
alleles = 1
common_alleles = 1
rare_alleles = 0
alias = A28
broad = 28 | sister1 = 68
allele1 = 01
nick1 = A69
lead_comment = (A*6901) is a derivative of the A*6801 allele that has undergone gene conversion with A*02. The recombination took place no more than 330,000 years agocite journal | author = Holmes N, Parham P | title = Exon shuffling "in vivo" can generate novel HLA class I molecules | journal = EMBO J. | volume = 4 | issue = 11 | pages = 2849–54 | year = 1985 | pmid = 3877632 | doi = ]
mode = Levant
types = 4
2ndType = 28
3rdType = 68
4thType = 2
type1alle1freq = 7 | type2alle1freq = 56 | type3alle1freq = 3 | type4alle1freq = 6| N1 = 289
serotype_comment = is poor, with low specific detection, high non-specific identification by A28, and false recognition by A68 and A2

Distribution

Distribution of A69 places nodal center in the Levant, but high levels in West Africa. The model of human genetic origin places first migrations from Eastern Africa. However in many east African populations the frequency of A69 is zero. A more consistent model of A69 distribution is either a subsequent migration from West Africa, supported by A36 and HLA DR3-DQ2. The higher levels in the Gaza Palestinians supports this hypothesis.

Disease associations

A69 may be associated with sarcoidosis.cite journal | author = Bilir M, Sipahi S, Yilmaz E, "et al" | title = Analysis of HLA antigens in Turkish sarcoidosis patients | journal = South. Med. J. | volume = 100 | issue = 4 | pages = 356–9 | year = 2007 | pmid = 17458393 | doi = ]

References