HLA-A36

HLA-A36

SerotypeA_normal
locus = A
type = 36
allelegroup = 36
oneallele = 01
alleles = 1
alias =
nick1 = A36
allele1 = 01
dominant = 01
mode = Africa (North and East) and Central Asia
lead_comment = is rare HLA-A allele group
types = 2
2ndType = 1
type1alle1freq = 68 |type2alle1freq = 16 |N1 = 807
serotype_comment = has a high false serotyping rate to A1

Distribution

A36 is largely limited to Africa. Outside of Africa more than half of the populations have no A36 and the majority that do, have only trace levels. The exception is in Central/East Central Asia. This appears not to be coincidental. HLA DR3-DQ2 linkage and frequency indicates a strong possibility of a recent migration from either North or West Africa in which the DR3-DQ2 (notably DRB1*0302) and A*33-B*58 haplotypes were carried into and redistributed from Central Asia into the surrounding populations.

References


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