Guijo de Santa Bárbara

Infobox City
official_name = Guijo de Santa Bárbara, Spain | nickname = |
| image_
|
| map_caption = | subdivision_type = Country | subdivision_name = Spain | subdivision_type1 = Autonomous community | subdivision_name1 = Extremadura | subdivision_type2 = Province | subdivision_name2 = Cáceres | subdivision_type3 = Municipality | subdivision_name3 = Guijo de Santa Bárbara | leader_title = | leader_name = | area_magnitude = | area_total_km2 = 35 | area_land_km2 = | area_water_km2 = | elevation_m = 876 | population_as_of = 2005 | population_note = | population_total = 429 | population_density_km2 = 12.3 | timezone = CET | utc_offset = +1 | timezone_DST = CEST | utc_offset_DST = +2 | latitude = 40º09' N | longitude = 5º39' W | website = | footnotes = |

Guijo de Santa Bárbara is a municipality located in the province of Cáceres, Extremadura, Spain. According to the 2005 census (INE), the municipality has a population of 429 inhabitants.