- Triple negative breast cancer
It is now commonly understood that
breast cancer is not one form ofcancer , but many different "subtypes" of cancer. [ [http://www.nature.com/nrc/journal/v7/n9/abs/nrc2193.html] [http://mednews.wustl.edu/news/page/normal/6358.html] ] These subtypes of breast cancer are generally diagnosed based upon the presence, or lack of, three "receptors" known to fuel most breast cancers:estrogen receptor ,progesterone receptor andHer2/neu . [ [http://www.medscape.com/viewarticle/554234 Log In Problems ] ] The most successful treatments for breast cancer target these receptors. [ [http://www.medicalnewstoday.com/articles/66261.php 'Triple Negative' Breast Cancers Linked To The Young, Minority ] ]None of these receptors are found in women with triple negative breast cancer. A triple negative breast cancer diagnosis means that the offending tumor is estrogen receptor-negative, progesterone receptor-negative and HER2-negative, thus giving rise to the name "triple negative breast cancer." [ [http://cancer.emory.edu/news/story.php?id=841] [http://www.medscape.com/viewarticle/554234] ] On a positive note, this type of breast cancer is typically responsive to chemotherapy. [ [http://annonc.oxfordjournals.org/cgi/content/extract/18/1/202 High-dose chemotherapy for triple negative breast cancer - De Giorgi et al. 18 (1): 202 - Annals of Oncology ] ] Because of its triple negative status, however, triple negative tumors generally do not respond to receptor targeted treatments. [ [http://www.medscape.com/viewarticle/554234] [http://www.medicalnewstoday.com/articles/66261.php] ] Depending on the stage of its diagnosis, triple negative breast cancer can be particularly aggressive, and more likely to recur than other subtypes of breast cancer. [ [http://clincancerres.aacrjournals.org/cgi/content/abstract/13/15/4429] [http://www.medscape.com/viewarticle/554234] [http://www.medicalnewstoday.com/articles/66261.php] ]
Triple negative breast cancer accounts for approximately 15% of all breast cancer cases. [ [http://www.cancerhelp.org.uk/help/default.asp?page=26093 Triple negative breast cancer ] ] It occurs most often in African American and younger women. [ [http://www.cancer.gov/ncicancerbulletin/NCI_Cancer_Bulletin_072407/page7] [http://www.medscape.com/viewarticle/554234] [http://www.docguide.com/news/content.nsf/news/852571020057CCF685257145006C69FC?OpenDocument&id=48DDE4A73E09A969852568880078C249&c=Breast%20Cancer&count=10] [http://www.forbes.com/health/feeds/hscout/2007/03/26/hscout603073.html] ] Because it is a recently recognized form of breast cancer, there is very little known about its pathology. [ [http://cancer.emory.edu/news/story.php?id=841 News Detail ] ] With a view towards finding better treatment options for this disease,
The Triple Negative Breast Cancer Foundation , together withSusan G. Komen for the Cure convened the Triple Negative Breast Cancer Symposium in December 2007. The Symposium brought together over 30 leading doctors, researchers and scientists from around the world for a think tank aimed at exploring the most promising research leads in the area of triple negative breast cancer.Basal-like carcinoma
It is currently understood that triple-negative tumors are composed of several distinct pathologic groups, the largest called
basal-like carcinoma of the breast. This newly proposed category of breast cancer is defined on the basis of its gene expression and protein expression profile.References
ee also
The Triple Negative Breast Cancer Foundation External links
* [http://www.tnbcfoundation.org/ The Official Triple Negative Breast Cancer Foundation Site]
* [http://www.http://www.tnbcfoundation.org/tnbc/forum/default.asp/ Triple Negative Breast Cancer Discussion Forum]
* [http://www.cancerhelp.org.uk/help/default.asp?page=26093/ Information about Triple Negative Breast Cancer]
* [http://www.komen.org Susan G. Komen for the Cure]
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