Anaphylatoxin

Anaphylatoxin

Anaphylatoxins, or anaphylotoxins, are fragments (C3a, C4a and C5a) that are produced during the pathways of the complement system.cite journal | author = Hugli TE | title = Biochemistry and biology of anaphylatoxins | journal = Complement | volume = 3 | issue = 3 | pages = 111–27 | year = 1986 | pmid = 3542363 | doi = | url = | accessdate = ]

Functions

Anaphylatoxin is able to trigger degranulation of (release of substances from) mast cells or basophils, which is an important part of the immune system in all kinds of inflammation and especially as part of defense against parasites. If the degranulation is too strong, it can cause allergic reactions.

Anaphylatoxins indirectly mediate:
*spasms of smooth muscle cells, for example bronchospasms
*increase in the permeability of blood capillaries
*chemotaxis — receptor-mediated movement of leukocytes in the direction of the increasing concentration of anaphylatoxins

Examples

Important anaphylatoxins:

* C3a is not as strong as C5a, but stronger than C4a and can trigger degranulation of Mast-cells and serve as a chemotactic targeting molecule for eosinophile granulocytes.
* C4a is the least active anaphylatoxin
* C5a is the strongest toxin in the row, it is a very strong mediator of inflammation.
** co-stimulation of C3b at times of phagocytosis (not possible without C5a).
** Chemotactor and activator for granulocytes in general and macrophages
** stimulates respiratory burst in Neutrophils
** increases vascular permeability
** contracts smooth muscle cells
** activates mast cells to release Histamine and TNF-Alpha

Terminology

Although some drugs (morphine, codeine, synthetic ACTH) and some neurotransmitters (norepinephrine, substance P) are important mediators of degranulation of mast cells or basophils, they are generally not called anaphylatoxins. This term is reserved only for fragments of the complement.

See also

*Allergy
*Anaphylatoxin receptors
*Anaphylaxis
*Complement system
*Inflammation
*Immune system
*Nervous system

References

External links

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Look at other dictionaries:

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  • anaphylatoxin — Low molecular weight substances generated by the activation of complement; the biologically active complement components are derived from C3, C4, and C5 and lead to increased vascular permeability as a result of the degranulation of primarily… …   Medical dictionary

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  • anaphylatoxin inactivator — An α globulin (MW 300,000) which destroys the activity of the anaphylatoxic complement fragments. See anaphylatoxin. * * * (AI) a serum carboxypeptidase that destroys the anaphylatoxin activity of C3a, C4a, and C5a by removing C terminal arginyl… …   Medical dictionary

  • anaphylatoxin — Originally used of an antigen that reacted with an IgE antibody thus precipitating reactions of anaphylaxis. Now restricted to defining a property of complement fragments C3a and C5a, both of which bind to the surfaces of mast cells and basophils …   Dictionary of molecular biology

  • anaphylatoxin — noun Any of several toxic substances that trigger anaphylaxis …   Wiktionary

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  • anaphylatoxin — an·a·phyl·a·tox·in …   English syllables

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  • C3a receptor — The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein coupled receptor protein involved in the complement system.cite journal | author = Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD | title = cDNA… …   Wikipedia

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