Non-stop decay

Non-stop decay

Non-stop decay is a cellular mechanism of mRNA surveillance to detect mRNA molecules lacking a stop codon and prevent these mRNAs from translation. The non-stop decay pathway releases ribosomes that have reached the far 3' end of an mRNA and guides the mRNA to the exosome complex for degradation. [1]

See also

References

  1. ^ Vasudevan et al.; Peltz, SW; Wilusz, CJ (2002). "Non-stop decay--a new mRNA surveillance pathway". Bioessays 24 (9): 785–8. doi:10.1002/bies.10153. PMID 12210514. 

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