Human Proteome Folding Project
- Human Proteome Folding Project
The Human Proteome Folding Project (HPF) is a collaborative effort between New York University (Bonneau Lab), the Institute for Systems Biology (ISB) and the University of Washington (Baker Lab), using the Rosetta software developed by the latter (Rosetta@home project).
The HPF project is currently in Phase 2, which is running exclusively on the World Community Grid. Phase 1 ran on two distributed computing grids: the World Community Grid, an IBM philanthropic initiative, and on United Devices' grid.org.
The Institute for Systems Biology designed the Human Proteome Folding project for World Community Grid and will use the results within its larger research efforts.
Current project status
HPF Phase 1 applied Rosetta v4.2x software on the human genome and 89 others, starting in November 2004. Phase 1 ended in July 2006. HPF Phase 2 (HPF2) applies the latest Rosetta v4.8x software in higher resolution, "full atom refinement" mode, concentrating on cancer biomarkers (proteins found at dramatically increased levels in cancer tissues), human secreted proteins and malaria.
Publications
Citation
last = Malmström
first = Lars
author-link =
last2 = Riffle
first2 = Michael
author2-link =
last3 = Strauss
first3 = Charlie E. M.
author3-link =
last4 = Chivian
first4 = Dylan
author4-link =
last5 = Davis
first5 = Trisha N.
author5-link =
last6 = Bonneau
first6 = Richard
author6-link =
last6 = Baker
first6 = David
author6-link =
title = Superfamily Assignments for the Yeast Proteome through Integration of Structure Prediction with the Gene Ontology
journal = PLoS Biology
volume = 5
number = 4
date =
year = 2007
url = http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050076&ct=1
doi = 10.1371/journal.pbio.0050076
id =
ee also
* World Community Grid
* Folding@home
* Rosetta@home
* List of distributed computing projects
* BOINC
External links
* [http://www.systemsbiology.org/Scientists_and_Research/Technology/Data_Visualization_and_Analysis/Human_Proteome_Folding_Project Human Proteome Folding at ISB]
* [http://www.worldcommunitygrid.org/projects_showcase/viewHpfResearch.do HPF page at WCG]
* [http://www.grid.org/projects/hpf/ HPF page at grid.org]
* [http://homepages.nyu.edu/%7erb133/wcg/rbonneau_posts.html HPF updates by Dr. Bonneau]
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