RNA integrity number

RNA integrity number

The RNA integrity number (RIN) is an algorithm for assigning integrity values to RNA measurements.

The integrity of RNA is a major concern for gene expression studies and traditionally has been evaluated using the 28S to 18S rRNA ratio, a method that has been shown to be inconsistent. The RIN algorithm was devised to overcome this issue. The RIN algorithm is applied to electrophoretic RNA measurements and based on a combination of different features that contribute information about the RNA integrity to provide a more robust universal measure.

External links

* [http://www.chem.agilent.com/Scripts/generic.asp?lPage=14975&indcol=Y&prodcol=Y RIN information from Agilent Technologies]
* [http://www.biomedcentral.com/1471-2199/7/3 RIN article in BMC Molecular Biology]
* [http://www.quantiom.de/RIN RIN page from quantiom bioinformatics]
* [http://RNA-integrity.gene-quantification.info/ More info here => http://RNA-integrity.gene-quantification.info]


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