Pel-Ebstein fever

Pel-Ebstein fever

Infobox_Disease
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eMedicineSubj = med
eMedicineTopic = 1770
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Pel-Ebstein fever is a rarely seen condition noted in patients with Hodgkin's lymphoma in which the patient experiences fevers which cyclicly increase then decrease over an average period of one or two weeks. A cyclic fever may also be associated with other conditions, but it is not called "Pel-Ebstein fever" unless the fever is associated with Hodgkin's.cite web |url=http://www.emedicine.com/med/topic1770.htm |title=eMedicine - Pel-Ebstein Fever : Article by Ephraim P Hochberg, MD |accessdate=2007-07-08 |format= |work=]

Causes

The cause is currently unknown although speculation centers on host immune response, lymph node necrosis, and damaged stomal cells. [ cite journal | last=Ree | first=HJ | title=Stromal macrophage-histiocytes in Hodgkin's disease. Their relation to fever. | journal=Cancer | volume=60 | issue=1479 | date=1987 ]

Treatment

Treatment with non-steroidal anti-inflammatory agents or treatment of the underlying Hodgkin's (usually with chemotherapy) will help the symptoms. cite book | last=Mauch | first=Peter | coauthors=James Armitage, Volker Diehl, Richard Hoppe, Laurence Weiss | title=Hodgkin's Disease | publisher=Lippincott Williams & Wilkins | date=1999 | pages=327–328 | isbn=0-7817-1502-4 ]

Eponym

The condition is named after Wilhelm Ebstein and PK Pel who both published papers in 1887 noting the phenomenon. [ cite journal | last=Ebstein | first=Wilhelm | authorlink=Wilhelm Ebstein | title=Das chronische Ruckfallsfieber, eine neue Infectionskrankheit | journal=Berlin Klin Wochenschr | volume=24 | issue=565
date=1887 ] [ cite journal | last=Pel | first=PK | title=Pseudoleukaemie oder chronisches Ruckfallsfieber? | journal=Berlin Klin Wochenschr | volume=24 | issue=565 | date=1887 ] WhoNamedIt|synd|438]

Controversy

Researchers have speculated whether this condition truly exists, since some authorities anecdotally estimate only a 5-10% occurrence rate. In his Lettsomian Lecture "Making Sense", delivered to the Medical Society of London in 1959, Richard Asher refers to Pel-Ebstein fever as an example of a condition that exists only because it has a name. "Every student and every doctor knows that cases of Hodgkin's disease may show a fever that is high for one week and low for the next week and so on. Does this phenomenon really exist at all?..." Stuart Bennett, a student from the University of Portsmouth confirms that this condition does exist, after suffering with the symptoms for over a year before his doctors gave a diagnosis. [Citation
last = Hilson
first = A.J.W.
last2 = DiNubile
first2 = M.J.
title = Correspondence
journal = New England Journal of Medicine
volume = 333
pages = 66–67
date = 1995-07-06
year = 1995
url = http://content.nejm.org/cgi/content/short/333/1/66
accessdate = 2008-03-18
id =
doi = 10.1056/NEJM199507063330118 . They cite Richard Asher's lecture "Making Sense" (Lancet, 1959, 2, 359)]

References


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Look at other dictionaries:

  • Pel-Ebstein fever — a cyclic fever occasionally seen in Hodgkin disease or certain other diseases, characterized by irregular episodes of pyrexia of several days duration, with intervening afebrile periods lasting for days or weeks. Called also Murchison Pel Ebstein …   Medical dictionary

  • Murchison-Pel-Ebstein fever — Mur·chi·son Pel Eb·stein fever (murґchĭ sən pelґ ebґshtīn) [Charles Murchison, British physician, 1830–1879; Pieter Klaases Pel, Dutch physician, 1852–1919; Wilhelm Ebstein, German physician, 1836–1912] Pel Ebstein fever …   Medical dictionary

  • Pel-Ebstein fever (disease) — Pel Eb·stein fever (disease) (pelґ ebґshtīn) [Pieter Klaases Pel, Dutch physician, 1852–1919; Wilhelm Ebstein, German physician, 1836–1912] see under fever …   Medical dictionary

  • Murchison-Pel-Ebstein fever — Pel Ebstein f …   Medical dictionary

  • Fièvre de Pel-Ebstein — Pour les articles homonymes, voir Pel et Ebstein. La fièvre de Pel Ebstein est un phénomène rare observé dans la maladie de Hodgkin[1], au cours de laquelle la température centrale des patients augmente et décroît de façon cyclique sur une ou… …   Wikipédia en Français

  • Pel-Ebstein disease — see under fever …   Medical dictionary

  • Fever — (also known as pyrexia, from the Greek pyretos meaning fire, or a febrile response, from the Latin word febris , meaning fever, and archaically known as ague) is a frequent medical sign that describes an increase in internal body temperature to… …   Wikipedia

  • Fever — Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.).… …   Medical dictionary

  • Pel — Pieter K., Dutch physician, 1852–1919. See P. Ebstein disease, P. Ebstein fever. * * * peritoneal exudate lymphocyte; permissible exposure limit …   Medical dictionary

  • Ebstein — Wilhelm, German physician, 1836–1912. See E. anomaly, E. disease, E. sign, Armanni E. change, Armanni E. kidney, Pel E. disease, Pel E. fever …   Medical dictionary

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