Louise McCullough

Louise McCullough M.D., Ph.D is a practicing vascular neurologist and associate professor who is actively engaged in stroke research at the University of Connecticut Health Center (UCHC) in Farmington, Connecticut in the United States. She provides neurological care at both the John Dempsey Hospital in Farmington, CT and the Hartford Hospital in Hartford, CT, which has a state-of-the-art stroke center [http://www.harthosp.org/stroke/AboutUs/default.aspx] . She is the director of stroke research at the department of neurology and neuroscience at UCHC and participates in teaching, research, medicine, and graduate student mentoring.

Research

Dr. McCullough is perhaps best known for her research identifying gender-based differences in cell death pathways during cerebral ischemia using neuronal nitric oxide synthase (nNOS) and poly ADP ribose polymerase-1 (PARP-1) knockout models which was published in the "Journal of Cerebral Blood Flow & Metabolism" (2005). [cite journal |author=McCullough LD, Zeng Z, Blizzard KK, Debchoudhury I, Hurn PD |title=Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection |journal=J. Cereb. Blood Flow Metab. |volume=25 |issue=4 |pages=502–12 |year=2005 |pmid=15689952 |doi=10.1038/sj.jcbfm.9600059] This paper was relevant as PARP-inhibiting drugs are currently undergoing clinical trials in a variety of pathologies. [cite web |url=http://www.eddn.org/clinicalTr_caResUK.html |title=EDDN - Clinical Trials - Cancer Research UK |accessdate=2008-03-25] Her current research is aggressively investigating the differences in cell death pathways as well as regulation of energy utilization during cerebral ischemia. [cite journal |author=McCullough LD, Zeng Z, Li H, Landree LE, McFadden J, Ronnett GV |title=Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke |journal=J. Biol. Chem. |volume=280 |issue=21 |pages=20493–502 |year=2005 |pmid=15772080 |doi=10.1074/jbc.M409985200]

Biography

After graduating from the University of Connecticut (Storrs campus), Dr. McCullough obtained her Ph.D from UCONN at Storrs and proceeded to obtain her medical degree from UCONN as well. Her neurology residency and subsequent postdoctoral training were both completed at Johns Hopkins University. In May 2007 Dr. McCullough was elected to be on the editorial board of the Journal "Stroke" [http://stroke.ahajournals.org/] , published by the American Heart Association (AHA). She was interviewed on May 23rd, 2007 by the NBC network and appeared on TV later that month. She has grants funded by both the National Institutes of Health (NIH) and the American Heart Association.

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