Small nucleolar SNORD12/SNORD106

In molecular biology, the small nucleolar RNAs SNORD106 and SNORD12 (also known as U106 and HBII-99 respectively ) are two related snoRNAs which belongs to the C/D class of small nucleolar RNAs (snoRNAs). Both contain the conserved C (UGAUGA) and D (CUGA) box sequence motifs [cite journal | last = Vitali | first = P | coauthors = Royo H, Seitz H, Bachellerie JP, Huttenhofer A, Cavaille J | year = 2003 | title = Identification of 13 novel human modification guide RNAs | journal = Nucleic Acids Res. | volume = 31 | pages = 6543–6551 | pmid = 14602913 | doi = 10.1093/nar/gkg849]

Human SNORD12 (HBII-99) is the homologue of mouse snoRNA MBII-99. In humans both HB11-99 and U106 snoRNAs share the same host gene.cite journal | last = Lestrade | first = L | coauthors = Weber MJ | year = 2006 | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Res. | volume = 34 | pages = D158–D162 | pmid = 16381836 | doi = 10.1093/nar/gkj002] Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. HBII-99 is predicted to guide the 2'O-ribose methylation of 28S rRNA G3878. [cite journal | last = Huttenhofer | first = A | coauthors = Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J | year = 2001 | title = RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse | journal = EMBO J. | volume = 20 | pages = 2943–2953 | pmid = 11387227 | doi = 10.1093/emboj/20.11.2943] U106 contains conserved antisense elements which would predict U106 methylates residues G1536 and U1602 of 18S rRNA. [cite journal | last = Kiss | first = T | year = 2002 | title = Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions | journal = Cell. | volume = 109 | pages = 145–148 | pmid = 12007400 | doi = 10.1016/S0092-8674(02)00718-3] However, these targets do not appear to be methylated and U106 might function as an RNA chaperone during rRNA folding. A similar role has been suggested for the H/ACA snoRNAs U17a and U17b

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