Human parechovirus 1 (HPeV1) cis regulatory element (CRE)

The Human Parechovirus 1 cis regulatory element is an RNA element which is located in the 5'-terminal 112 nucleotides of the genome of human parechovirus 1 (HPeV1). The element consists of two stem-loop structures (SL-A and SL-B) together with a pseudoknot. Disruption of any of these elements impairs both viral replication and growth. [cite journal | last = Nateri | first = AS | coauthors = Hughes PJ, Stanway G | year = 2002 | title = Terminal RNA replication elements in human parechovirus 1 | journal = J Virol | volume = 76 | pages = 13116–13122 | pmid = 12438643 | doi = 10.1128/JVI.76.24.13116-13122.2002]

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