Small nucleolar RNA Z13/snr52

Small nucleolar RNA snR52 (homologous to Z13) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.snoRNA Z13 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .snoRNA snR52 was initially discovered using a computational screen of the "Saccharomyces cerevisiae" genomecite journal |author=Lowe TM, Eddy SR |title=A computational screen for methylation guide snoRNAs in yeast |journal=Science |volume=283 |issue=5405 |pages=1168–71 |year=1999 |pmid=10024243 |doi=] , subsequent work identified Z13 in "Schizosaccharomyces pombe". Further experiments have shown that snR52 is transcribed by RNA polymerase III cite journal |author=Harismendy O, Gendrel CG, Soularue P, "et al" |title=Genome-wide location of yeast RNA polymerase III transcription machinery |journal=EMBO J. |volume=22 |issue=18 |pages=4738–47 |year=2003 |pmid=12970186 |doi=10.1093/emboj/cdg466] cite journal |author=Marck C, Kachouri-Lafond R, Lafontaine I, Westhof E, Dujon B, Grosjean H |title=The RNA polymerase III-dependent family of genes in hemiascomycetes: comparative RNomics, decoding strategies, transcription and evolutionary implications |journal=Nucleic Acids Res. |volume=34 |issue=6 |pages=1816–35 |year=2006 |pmid=16600899 |doi=10.1093/nar/gkl085] .

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External links

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* [http://people.biochem.umass.edu/sfournier/fournierlab/snornadb/snrs/snr52_ta.php Link to snR52 at the FournierLab/snoRNAdb.]