FGF-2 internal ribosome entry site (IRES)

The FGF-2 internal ribosome entry site is an RNA element present in the 5' UTR of the mRNA of fibroblast growth factor-2. It has been found that the FGF-2 internal ribosome entry site (IRES) activity is strictly controlled and highly tissue specific. It is thought that translational IRES dependent activation of FGF-2 plays a vital role in embryogenesis and in the adult brain [1] . When expressed the fibroblast growth factor 2 FGF-2 protein plays a pivotal role in cell proliferation, differentiation and survival as well as being involved in wound-healing [1,2] .

References

* [1] cite journal | last = Creancier | first = L | coauthors = Morello D, Mercier P, Prats AC | year = 2000 | title = Fibroblast growth factor 2 internal ribosome entry site (IRES) activity ex vivo and in transgenic mice reveals a stringent tissue-specific regulation | journal = J Cell Biol | volume = 150 | pages = 275–281 | pmid = 10893274 | doi = 10.1083/jcb.150.1.275
* [2] cite journal | last = Vagner | first = S | coauthors = Gensac MC, Maret A, Bayard F, Amalric F, Prats H, Prats AC | year = 1995 | title = Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes | journal = Mol Cell Biol | volume = 15 | pages = 35–44 | pmid = 7799942

External links

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