FGF-1 internal ribosome entry site (IRES)

The FGF-1 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of fibroblast growth factor-1 and allows cap-independent translation. It is thought that FGF-1 internal ribosome entry site (IRES) activity is strictly controlled and highly tissue specific. [cite journal | last = Martineau | first = Y | coauthors = Le Bec C, Monbrun L, Allo V, Chiu IM, Danos O, Moine H, Prats H, Prats AC | year = 2004 | title = Internal Ribosome Entry Site Structural Motifs Conserved among Mammalian Fibroblast Growth Factor 1 Alternatively Spliced mRNAs | journal = Mol Cell Biol | volume = 24 | pages = 7622–7635 | pmid = 15314170 | doi = 10.1128/MCB.24.17.7622-7635.2004]

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