HLA-DM

protein
Name = major histocompatibility complex, class II, DM alpha
caption =


width =
HGNCid = 4934
Symbol = HLA-DMA
AltSymbols =
EntrezGene = 3108
OMIM = 142855
RefSeq = NM_006120
UniProt = P28067
PDB =
ECnumber =
Chromosome = 6
Arm = p
Band = 21.3
LocusSupplementaryData = protein
Name = major histocompatibility complex, class II, DM beta
caption =


width =
HGNCid = 4935
Symbol = HLA-DMB
AltSymbols =
EntrezGene = 3109
OMIM = 142856
RefSeq = NM_002118
UniProt = P28068
PDB =
ECnumber =
Chromosome = 6
Arm = p
Band = 21.3
LocusSupplementaryData =

HLA-DM is an intracellular protein involved in peptide presentation by MHC class II.cite journal | author = Busch R, Rinderknecht CH, Roh S, Lee AW, Harding JJ, Burster T, Hornell TM, Mellins ED | title = Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression | journal = Immunol. Rev. | volume = 207 | issue = | pages = 242–60 | year = 2005 | month = October | pmid = 16181341 | doi = 10.1111/j.0105-2896.2005.00306.x | url = | issn = ] It is encoded by the genes Gene|HLA-DMA and Gene|HLA-DMB.

In the endosomes, HLA-DM functions by promoting the dissociation of the CLIP peptide (a place holder peptide) from MHC class II which allows endosomal peptides to bind. Possibly by its preferential binding of the open, peptide-less conformation of MHC class II, HLA-DM then catalyzes peptide exchange, favoring more stable peptide-MHC complexes (which are resistant to DM action). Thus, HLA-DM is thought to play an important role in "editing" the peptide repertoire.

References

External links

* [http://www.bio.davidson.edu/Courses/immunology/Students/spring2006/McCracken/HLA-DM.html Overview] at Davidson College (student generated)