RAMP3

RAMP3

protein
Name = receptor (G protein-coupled) activity modifying protein 3
caption =


width =
HGNCid = 9845
Symbol = RAMP3
AltSymbols =
EntrezGene = 10268
OMIM = 605155
RefSeq = NM_005856
UniProt = O60896
PDB =
ECnumber =
Chromosome = 7
Arm = p
Band = 13
LocusSupplementaryData = -p12

Receptor activity modifying protein 3, also known as RAMP3, is a human gene.cite web | title = Entrez Gene: RAMP3 | url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10268 | accessdate =] cite journal | author =McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM | title = RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor | journal = Nature | volume = 393 | issue = 6683 | pages = 333–9 | year = 1998 | month = May | pmid = 9620797 | doi = 10.1038/30666 | url = |issn = ]

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.

References


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