- Lars Leksell
Infobox Medical Person
name =Lars Leksell
November 23 1907
death_date =1986 (aged 78)
known_for =Invention of
University of Lund
Lars Leksell (1907-1986) was a Swedish
physicianand Professor of Neurosurgeryat the Karolinska Institutein Stockholm, Sweden. He was the inventor of radiosurgery.
Life and work
Lars Leksell was born in
Fassberg, Swedenon November 23 1907. He graduated in Medicineat the Karolinska Institute in 1935 and began training in neurosurgery in the same year. He became a professor of surgery at University of Lundin 1958. From 1960 until his retirement, in 1974, he was Professor of Neurosurgery at the Karolinska Institute in Stockholm, succeeding Herbert Olivecrona, who was the department's founder in 1920. He died in 1986.
Professor Lars Leksell was one of the first to develop a stereotactic apparatus exclusively for human functional
neurosurgeryin 1949, following the pioneering work of American neurosurgeons Ernest A. Spiegeland Henry T. Wycisin 1947. It was based on the Horsley-Clarke apparatusdeveloped for animal experimentationby the British neurosurgeon Sir Victor Horsleyat University College Londonin 1908, but instead of using the cartesiancoordinate frame, it used polar coordinates. The Leksell Stereotactic Frame was and still is in wide use today. Using it, Leksell and his collaborators stand also among the pioneers in the surgical approach to the treatment of Parkinson's Disease, a degenerative condition of the motor system of the brain, by precisely lesioning a small structure in the basal ganglia, by means of an operation called pallidotomy.
In 1951, using the
Uppsala University cyclotron, Leksell and the physicist and radiobiologist Borje Larsson, developed the concept of radiosurgery. Leksell and Larsson first employed proton beamscoming from several directions into a small area into the brain, in experiments in animals and in the first treatments of human patients. He called this technique "strålkniven" (ray knives). Thus, he achieved a new non-invasive methodof destroying discrete anatomical regions within the brain while minimizing the effect on the surrounding tissues. Later, a special apparatus known as the "Gamma Knife", was developed by Lars Leksell in 1968. It is a sterotactice device which contains multiple radioactive cobaltsources and is dedicated solely to radiosurgery. Today, Leksell's technique is used as an effective treatment for many conditions such as vestibular schwannomas (first surgery performed at Karolinska in 1969), pituitarytumors (also in 1969), arteriovenous malformations (in 1970), craniopharyngiomas, meningiomas (in 1976), metastaticand skullbase tumors(in 1986), and primary brain tumors. The Leksell Gamma Knifeis manufactured by Elekta Instruments AB, a Swedish company which manufactures stereotactical surgery and radiosurgery equipment, based on the inventions of Lars Leksell. It was founded by him and his son, Laurent Leksell, in 1972.
Lars Leksell served as a mentor for a number of other leading neurosurgeons including L. Dade Lunsford who established the first U.S.
Gamma Knifecenter at the University of Pittsburghand John Adler, the inventor of Cyberknife.
Leksell has worked also in
neurophysiology. His most noted contribution was the description of the gamma motor systemof the nervous system.
"Tools used by the surgeon must be adapted to the task and where the human brain is concerned, no tool can be too refined." Lars Leksell.
To know more
* The History of Stereotactical Radiosurgery, by Stephen B. Tatter, MD, PhD, Massachusetts General Hospital, Dept. Neurosurgery.
* Montagno, E.A. and Sabbatini, R.M.E. - [http://www.cerebromente.org.br/n02/tecnologia/radiocirurg_i.htm Radiosurgery] . Brain & Mind Magazine, June 1997
* [http://www.gammaknife.co.uk/internal/Overview/histgamma.pdf The History of Gamma Knife Surgery] (in PDF format)
* [http://www.elekta.com Elekta Instruments, Inc] , Home Page
* Lunsford LD: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9311073 Lars Leksell. Notes at the side of a raconteur] . Stereotact Funct Neurosurg. 1996-97;67(3-4):153-68.
* Larsson B, Leksell L, Rexed B, et al: The high energy proton beam as a neurosurgical tool. Nature 182:1222-3, 1958;
* Leksell L: The stereotaxic method and radiosurgery of the brain. Acta Chir Scand 102:316-19, 1951.
[http://www.cerebromente.org.br/n02/historia/psicocirg_i.htm The History of Psychosurgery]
Renato M.E. Sabbatini, PhD
[http://www.cerebromente.org.br Brain & Mind Magazine] , June 1997
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