Lipstatin

Chembox new
ImageFile = Lipstatin.svg
ImageSize = 250px
IUPACName = [(2"S",4"E",7"E")-1-(3-hexyl-4-oxo-oxetan-2-yl)
trideca-4,7-dien-2-yl] (2"S")-2-formamido-
3-methyl-pentanoate
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Section1 = Chembox Identifiers
CASNo = 96829-59-3
MeSHName = Lipstatin
PubChem = 6438672
ChemSpider = 7981411
SMILES = CCCCCCC1C(OC1=O)C [C@H] (CC=CCC=C
CCCCC)OC(=O) [C@H] (C(C)CC)NC=O
Section2 = Chembox Properties
Formula = C₂₉H₄₉NO₅
MolarMass = 491.703 g/mol
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Section3 = Chembox Hazards
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Lipstatin is a potent, irreversible inhibitor of pancreatic lipase. It is a natural product, and was first isolated from the Actinobacterium "Streptomyces toxytricini". [cite journal |author=Weibel E, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H |title=Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity |journal=J Antibiot (Tokyo) |volume=40 |issue=8 |pages=1081–5 |year=1987 |pmid=3680018]

The popular antiobesity drug orlistat (trade names Xenical and alli) is a saturated derivative of lipstatin.

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