Synovial fluid

Synovial fluid is a thick, stringy fluid found in the cavities of synovial joints. With its egg-like consistency ("synovial" partially derives from "ovum", Latin for egg), synovial fluid reduces friction between the articular cartilage and other tissues in joints to lubricate and cushion them during movement.

Overview

The inner membrane of synovial joints is called the synovial membrane and secretes synovial fluid into the joint cavity. This fluid forms a thin layer (roughly 50 μm) at the surface of cartilage, but also seeps into microcavities and irregularities in the articular cartilage surface, filling all empty space [http://www.ucl.ac.uk/~regfjxe/NORMALJOINT.htm] . The fluid within articular cartilage effectively serves as a synovial fluid reserve. During movement, the synovial fluid held within the cartilage is squeezed out mechanically to maintain a layer of fluid on the cartilage surface (so-called "weeping lubrication").

Composition

Synovial tissue is composed of vascularized connective tissue that lacks a basement membrane. Two cells type (type A and type B) are present: type B produce synovial fluid. Synovial fluid is made of hyaluronic acid and lubricin, proteinases and collagenases. Synovial fluid exhibits non-Newtonian flow characteristics. The viscosity coefficient is not a constant, the fluid is not linearly viscous, and its viscosity increases as the shear rate decreases.

Normal synovial fluid contains 3-4 mg/ml hyaluronan (hyaluronic acid), a polymer of disaccharides composed of D-glucuronic acid and D-N-acetylglucosamine joined by alternating beta-1,4 and beta-1,3 glycosidic bonds [ [http://www.glycoforum.gr.jp/science/hyaluronan/HA01/HA01E.html GlycoForum / Science of Hyaluronan-1 ] ] . Hyaluronan is synthesized by the synovial membrane and secreted into the joint cavity to increase the viscosity and elasticity of articular cartilages and lubricate the surfaces between synovium and cartilage. [ [http://www.orthop.washington.edu/arthritis/general/joints/04 Arthritis - UW Medicine - Department of Orthopaedics and Sports Medicine ] ]

Synovial fluid also contains lubricin secreted by synovial cells. It is chiefly responsible for so-called boundary-layer lubrication, which reduces friction between opposing surfaces of cartilage. There is also some evidence that it helps regulate synovial cell growth. [ [http://arthritis-research.com/content/5/S3/5 Arthritis Research & Therapy | Full text | Delineating biologic pathways involved in skeletal growth and homeostasis through the study of rare Mendelian diseases that affect bones and joints ] ]

Health and disease

Collection

Synovial fluid can be collected by syringe in a procedure termed arthrocentesis, also known as joint aspiration.

Classification

Synovial fluid can be classified into normal, noninflammatory, inflammatory, septic, and hemorrhagic:

Pathology

Many synovial fluid types are associated with specific diagnoses [ [http://www.fpnotebook.com/RHE64.htm Lupus Anticoagulant ] ] [ [http://www.rheumatology.org/publications/primarycare/number6/hrh0033698.asp?aud=mem American College of Rheumatology ] ] :

* Noninflammatory (Group I)
** Osteoarthritis, degenerative joint disease
** Trauma
** Rheumatic fever
** Chronic gout or pseudogout
** Scleroderma
** Polymyositis
** Systemic lupus erythematosus
** Erythema nodosum
** Neuropathic arthropathy (with possible hemorrhage)
** Sickle-cell disease
** Hemochromatosis
** Acromegaly
** Amyloidosis
* Inflammatory (Group II)
** Rheumatoid arthritis
** Reactive arthritis
** Psoriatic arthritis
** Acute rheumatic fever
** Acute gout or pseuodgout
** Scleroderma
** Polymyositis
** Systemic lupus erythematosus
** Ankylosing spondylitis
** Inflammatory bowel disease arthritis
** Infection (viral, fungal, bacterial) including Lyme disease
** Acute crystal synovitis
* Septic (Group III)
** Pyogenic bacterial infection
** Septic arthritis
* Hemorrhagic
** Trauma
** Tumors
** Hemophilia/coagulopathy
** Scurvy
** Ehlers-Danlos syndrome
** Neuropathic arthropathy

Joints cracking

When two parts forming a joint are pulled away from each other, the joint capsule increases in volume but the synovial fluid in the capsule no longer fills it all. Gases dissolved in the fluid quickly fill the empty space causing a sharp cracking sound. [ [http://health.howstuffworks.com/question437.htm Howstuffworks "What makes your knuckles pop?" ] ] The general term for this is cavitation.

=Additional

References

External links

* Warman W. "Delineating biologic pathways involved in skeletal growth and homeostasis through the study of rare Mendelian diseases that affect bones and joints." "Arthritis Res. Ther." 2003, 5(Suppl 3):5 [http://arthritis-research.com/content/5/S3/5]
* [http://www.glycoforum.gr.jp/science/hyaluronan/HA01/HA01E.html Hyaluronan: structure and properties]
* [http://www.ucl.ac.uk/~regfjxe/NORMALJOINT.htm Normal joint structure] , from University College London