Geranylgeranylation

Geranylgeranylation

Geranylgeranylation is a post-translational modification of proteins that involves the attachment of the isoprene geranylgeranyl diphosphate to the C-terminus at the cysteine residue. It is an intermediate step of the cholesterol biosynthesis pathway, which is used to modify the Rho GTPase family of signaling molecules.

An example of this can be seen in the lipid anchoring of the gamma subunit of heterotrimeric G proteins


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • geranylgeranylation — noun The introduction of a geranylgeranyl group into a molecule …   Wiktionary

  • CHML (gene) — Choroideremia like (Rab escort protein 2), also known as CHML, is a human gene.cite web | title = Entrez Gene: CHML choroideremia like (Rab escort protein 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • RAB5A — RAB5A, member RAS oncogene family, also known as RAB5A, is a human gene.cite web | title = Entrez Gene: RAB5A RAB5A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5868|… …   Wikipedia

  • RAB1A — RAB1A, member RAS oncogene family, also known as RAB1A, is a human gene.cite web | title = Entrez Gene: RAB1A RAB1A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5861|… …   Wikipedia

  • Posttranslational modification — (PTM) is the chemical modification of a protein after its translation. It is one of the later steps in protein biosynthesis for many proteins.A protein (also called a polypeptide) is a chain of amino acids. During protein synthesis, 20 different… …   Wikipedia

  • Bisphosphonate — Basic structure of a bisphosphonate on top. To compare the structure of pyrophosphate below. Note the similarity in structure. Bisphosphonates (also called diphosphonates) are a class of drugs that prevent the loss of bone mass, used to treat… …   Wikipedia

  • RAB3A — RAB3A, member RAS oncogene family, also known as RAB3A, is a human gene.cite web | title = Entrez Gene: RAB3A RAB3A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5864|… …   Wikipedia

  • RAB27A — RAB27A, member RAS oncogene family, also known as RAB27A, is a human gene.cite web | title = Entrez Gene: RAB27A RAB27A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5873|… …   Wikipedia

  • geranylgeranylated — adjective Modified by geranylgeranylation …   Wiktionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”