XRCC4

XRCC4

X-ray repair complementing defective repair in Chinese hamster cells 4, also known as XRCC4, is a human gene.cite web | title = Entrez Gene: XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7518| accessdate = ]

PBB_Summary
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summary_text = The [protein] encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. This gene contains 8 exons, and alternative transcription initiation and alternative splicing generates several transcript variants.cite web | title = Entrez Gene: XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7518| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lieber MR |title=The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes. |journal=Genes Cells |volume=4 |issue= 2 |pages= 77–85 |year= 1999 |pmid= 10320474 |doi=
*cite journal | author=Giaccia AJ, Denko N, MacLaren R, "et al." |title=Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant. |journal=Am. J. Hum. Genet. |volume=47 |issue= 3 |pages= 459–69 |year= 1990 |pmid= 1697445 |doi=
*cite journal | author=Otevrel T, Stamato TD |title=Regional localization of the XRCC4 human radiation repair gene. |journal=Genomics |volume=27 |issue= 1 |pages= 211–4 |year= 1995 |pmid= 7665175 |doi= 10.1006/geno.1995.1029
*cite journal | author=Li Z, Otevrel T, Gao Y, "et al." |title=The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. |journal=Cell |volume=83 |issue= 7 |pages= 1079–89 |year= 1996 |pmid= 8548796 |doi=
*cite journal | author=Grawunder U, Wilm M, Wu X, "et al." |title=Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. |journal=Nature |volume=388 |issue= 6641 |pages= 492–5 |year= 1997 |pmid= 9242410 |doi= 10.1038/41358
*cite journal | author=Critchlow SE, Bowater RP, Jackson SP |title=Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. |journal=Curr. Biol. |volume=7 |issue= 8 |pages= 588–98 |year= 1997 |pmid= 9259561 |doi=
*cite journal | author=Mizuta R, Cheng HL, Gao Y, Alt FW |title=Molecular genetic characterization of XRCC4 function. |journal=Int. Immunol. |volume=9 |issue= 10 |pages= 1607–13 |year= 1998 |pmid= 9352367 |doi=
*cite journal | author=Leber R, Wise TW, Mizuta R, Meek K |title=The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1794–801 |year= 1998 |pmid= 9430729 |doi=
*cite journal | author=Gao Y, Sun Y, Frank KM, "et al." |title=A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. |journal=Cell |volume=95 |issue= 7 |pages= 891–902 |year= 1999 |pmid= 9875844 |doi=
*cite journal | author=Modesti M, Hesse JE, Gellert M |title=DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity. |journal=EMBO J. |volume=18 |issue= 7 |pages= 2008–18 |year= 1999 |pmid= 10202163 |doi= 10.1093/emboj/18.7.2008
*cite journal | author=Nick McElhinny SA, Snowden CM, McCarville J, Ramsden DA |title=Ku recruits the XRCC4-ligase IV complex to DNA ends. |journal=Mol. Cell. Biol. |volume=20 |issue= 9 |pages= 2996–3003 |year= 2000 |pmid= 10757784 |doi=
*cite journal | author=Gao Y, Ferguson DO, Xie W, "et al." |title=Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. |journal=Nature |volume=404 |issue= 6780 |pages= 897–900 |year= 2000 |pmid= 10786799 |doi= 10.1038/35009138
*cite journal | author=Chen L, Trujillo K, Sung P, Tomkinson AE |title=Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26196–205 |year= 2000 |pmid= 10854421 |doi= 10.1074/jbc.M000491200
*cite journal | author=Lee KJ, Huang J, Takeda Y, Dynan WS |title=DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system. |journal=J. Biol. Chem. |volume=275 |issue= 44 |pages= 34787–96 |year= 2000 |pmid= 10945980 |doi= 10.1074/jbc.M004011200
*cite journal | author=Ford BN, Ruttan CC, Kyle VL, "et al." |title=Identification of single nucleotide polymorphisms in human DNA repair genes. |journal=Carcinogenesis |volume=21 |issue= 11 |pages= 1977–81 |year= 2000 |pmid= 11062157 |doi=
*cite journal | author=Sibanda BL, Critchlow SE, Begun J, "et al." |title=Crystal structure of an Xrcc4-DNA ligase IV complex. |journal=Nat. Struct. Biol. |volume=8 |issue= 12 |pages= 1015–9 |year= 2002 |pmid= 11702069 |doi= 10.1038/nsb725
*cite journal | author=Lee KJ, Dong X, Wang J, "et al." |title=Identification of human autoantibodies to the DNA ligase IV/XRCC4 complex and mapping of an autoimmune epitope to a potential regulatory region. |journal=J. Immunol. |volume=169 |issue= 6 |pages= 3413–21 |year= 2002 |pmid= 12218164 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hsu HL, Yannone SM, Chen DJ |title=Defining interactions between DNA-PK and ligase IV/XRCC4. |journal=DNA Repair (Amst.) |volume=1 |issue= 3 |pages= 225–35 |year= 2003 |pmid= 12509254 |doi=

External links

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