E. coli nitroreductase

"E. coli" nitroreductase is a flavoprotein found in the bacteria "Escherichia coli". It catalyses the reduction of nitro groups in a wide range of substrates, to produce the corresponding hydroxylamine. Although its role "in vivo" is unclear, it has been identified as useful in the metabolism of a number of prodrugs in anti-cancer gene therapy. [Denny, W.A. "Nitroreductase-based GDEPT" "Current Pharmaceutical Design", 2002, 8(15), 1349-1361.]

ee also

* Reduction of nitro compounds

References