Immunoreceptor tyrosine-based inhibitory motif
- Immunoreceptor tyrosine-based inhibitory motif
An immunoreceptor tyrosine-based inhibition motif (ITIM), is a conserved sequence of amino acids (S/I/V/LxYxxI/V/L) that is found in the cytoplasmic tails of many inhibitory receptors of the immune system. After ITIM-possessing inhibitory receptors interact with their ligand, their ITIM motif becomes phosphorylated by enzymes of the Src family of kinases, allowing them to recruite other enzymes such as the phosphotyrosine phosphatases SHP-1 and SHP-2, or the inositol-phosphatase called SHIP. These phosphatases decrease the activation of molecules involved in cell signaling. [cite journal |author=Barrow A, Trowsdale J |title=You say ITAM and I say ITIM, let's call the whole thing off: the ambiguity of immunoreceptor signalling |journal=Eur J Immunol |volume=36 |issue=7 |pages=1646–53 |year=2006 |pmid=16783855 |doi=10.1002/eji.200636195]
References
Wikimedia Foundation.
2010.
Look at other dictionaries:
ITIM — (= immunoreceptor tyrosine based inhibitory motif) Phosphorylation of the ITIM motif, found in the cytoplasmic tail of some inhibitory receptors (KIRs) that bind MHC Class I, leads to the recruitment and activation of a protein tyrosine… … Dictionary of molecular biology
Fc receptor — An Fc receptor is a protein found on the surface of certain cells including natural killer cells, macrophages, neutrophils, and mast cells that contribute to the protective functions of the immune system.Its name is derived from its binding… … Wikipedia
LILRB4 — Leukocyte immunoglobulin like receptor, subfamily B (with TM and ITIM domains), member 4, also known as LILRB4, is a human gene.cite web | title = Entrez Gene: LILRB4 leukocyte immunoglobulin like receptor, subfamily B (with TM and ITIM domains) … Wikipedia
PILRB — Paired immunoglobin like type 2 receptor beta, also known as PILRB, is a human gene.cite web | title = Entrez Gene: PILRB paired immunoglobin like type 2 receptor beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… … Wikipedia
PD-1 — Programmed Death 1, or PD 1, is a Type I membrane protein of 268 amino acids. PD 1 is a member of the extended CD28/CTLA 4 family of T cell regulators.[1] The protein s structure includes an extracellular IgV domain followed by a transmembrane… … Wikipedia
SIGLEC7 — Sialic acid binding Ig like lectin 7, also known as SIGLEC7, is a human gene.cite web | title = Entrez Gene: SIGLEC7 sialic acid binding Ig like lectin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… … Wikipedia
G protein-coupled receptor — G protein coupled receptors (GPCRs), also known as seven transmembrane domain receptors, 7TM receptors, heptahelical receptors, and G protein linked receptors (GPLR), comprise a large protein family of transmembrane receptors that sense molecules … Wikipedia
CD5 (protein) — CD5 is a cluster of differentiation found on a subset of IgM secreting B cells called B 1 cells, and also on T cells.cite web | title = Entrez Gene: CD5 CD5 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… … Wikipedia
MAFA — (Mast cell function associated antigen) is a type II membranal glycoprotein, first identified on the surface of rat mucosal type mast cells of the RBL 2H3 line. More recently, human and mouse homologues of MAFA have been discovered yet also (or… … Wikipedia
LILRA2 — Leukocyte immunoglobulin like receptor, subfamily A (with TM domain), member 2, also known as LILRA2, is a human gene.cite web | title = Entrez Gene: LILRA2 leukocyte immunoglobulin like receptor, subfamily A (with TM domain), member 2| url =… … Wikipedia
