Ebselen

Chembox new
ImageFile = Ebselen-2D-skeletal.png ImageSize = 200px
ImageName = Skeletal formula of ebselen
ImageFile1 = Ebselen-3D-balls.png ImageSize1 = 200px
ImageName1 = Ball-and-stick model of the ebselen molecule
IUPACName = 2-Phenyl-1,2-benzoselenazol-3-one
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Section1= Chembox Identifiers
CASNo= 60940-34-3
PubChem=3194
SMILES=C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3 [Se] 2
Section2= Chembox Properties
Formula=C₁₃H₉NOSe
MolarMass=274.17666
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Section3= Chembox Hazards
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Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite. [cite journal |author=Schewe T |title=Molecular actions of ebselen--an antiinflammatory antioxidant |journal=Gen Pharmacol |volume=26 |issue=6 |pages=1153–69 |year=1995 |pmid=7590103] It is being investigated as a possible treatment for reperfusion injury and stroke. [cite journal |author=Parnham M, Sies H |title=Ebselen: prospective therapy for cerebral ischaemia |journal=Expert Opin Investig Drugs |volume=9 |issue=3 |pages=607–19 |year=2000 |pmid=11060699 |doi=10.1517/13543784.9.3.607] [cite journal |author=Yamaguchi T, Sano K, Takakura K, Saito I, Shinohara Y, Asano T, Yasuhara H |title=Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group |url=http://stroke.ahajournals.org/cgi/content/full/29/1/12 |journal=Stroke |volume=29 |issue=1 |pages=12–7 |year=1998 |pmid=9445321]

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