[cite web | title = Entrez Gene: SFTPC surfactant, pulmonary-associated protein C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6440| accessdate = ] ]Pulmonary surfactant-associated protein C is a membrane protein which manufactures surfactant.
Humans and animals born lacking SP-C tend to develop progressive interstitial pneumonitis.
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References
Further reading
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*cite journal | author=Pérez-Gil J |title=Lipid-protein interactions of hydrophobic proteins SP-B and SP-C in lung surfactant assembly and dynamics. |journal=Pediatric pathology & molecular medicine |volume=20 |issue= 6 |pages= 445–69 |year= 2002 |pmid= 11699574 |doi=
*cite journal | author=Solarin KO, Wang WJ, Beers MF |title=Synthesis and post-translational processing of surfactant protein C. |journal=Pediatric pathology & molecular medicine |volume=20 |issue= 6 |pages= 471–500 |year= 2002 |pmid= 11699575 |doi=
*cite journal | author=Johansson J, Curstedt T, Robertson B |title=Artificial surfactants based on analogues of SP-B and SP-C. |journal=Pediatric pathology & molecular medicine |volume=20 |issue= 6 |pages= 501–18 |year= 2002 |pmid= 11699576 |doi=
*cite journal | author=Nogee LM |title=Alterations in SP-B and SP-C expression in neonatal lung disease. |journal=Annu. Rev. Physiol. |volume=66 |issue= |pages= 601–23 |year= 2004 |pmid= 14977415 |doi= 10.1146/annurev.physiol.66.032102.134711
*cite journal | author=Brasch F, Griese M, Tredano M, "et al." |title=Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene. |journal=Eur. Respir. J. |volume=24 |issue= 1 |pages= 30–9 |year= 2005 |pmid= 15293602 |doi=
*cite journal | author=Keller A, Eistetter HR, Voss T, Schäfer KP |title=The pulmonary surfactant protein C (SP-C) precursor is a type II transmembrane protein. |journal=Biochem. J. |volume=277 ( Pt 2) |issue= |pages= 493–9 |year= 1991 |pmid= 1859376 |doi=
*cite journal | author=Curstedt T, Johansson J, Persson P, "et al." |title=Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 8 |pages= 2985–9 |year= 1990 |pmid= 2326260 |doi=
*cite journal | author=Simatos GA, Forward KB, Morrow MR, Keough KM |title=Interaction between perdeuterated dimyristoylphosphatidylcholine and low molecular weight pulmonary surfactant protein SP-C. |journal=Biochemistry |volume=29 |issue= 24 |pages= 5807–14 |year= 1990 |pmid= 2383558 |doi=
*cite journal | author=Glasser SW, Korfhagen TR, Perme CM, "et al." |title=Two SP-C genes encoding human pulmonary surfactant proteolipid. |journal=J. Biol. Chem. |volume=263 |issue= 21 |pages= 10326–31 |year= 1988 |pmid= 2839484 |doi=
*cite journal | author=Glasser SW, Korfhagen TR, Weaver TE, "et al." |title=cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal). |journal=J. Biol. Chem. |volume=263 |issue= 1 |pages= 9–12 |year= 1988 |pmid= 3335510 |doi=
*cite journal | author=Johansson J, Jörnvall H, Eklund A, "et al." |title=Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of the human and bovine forms. |journal=FEBS Lett. |volume=232 |issue= 1 |pages= 61–4 |year= 1988 |pmid= 3366248 |doi=
*cite journal | author=Warr RG, Hawgood S, Buckley DI, "et al." |title=Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 22 |pages= 7915–9 |year= 1987 |pmid= 3479771 |doi=
*cite journal | author=Young WA |title=Familial fibrocystic pulmonary dysplasia: a new case in a known affected family. |journal=Canadian Medical Association journal |volume=94 |issue= 20 |pages= 1059–61 |year= 1966 |pmid= 5942662 |doi=
*cite journal | author=Wood S, Yaremko ML, Schertzer M, "et al." |title=Mapping of the pulmonary surfactant SP5 (SFTP2) locus to 8p21 and characterization of a microsatellite repeat marker that shows frequent loss of heterozygosity in human carcinomas. |journal=Genomics |volume=24 |issue= 3 |pages= 597–600 |year= 1995 |pmid= 7713515 |doi= 10.1006/geno.1994.1673
*cite journal | author=Hatzis D, Deiter G, deMello DE, Floros J |title=Human surfactant protein-C: genetic homogeneity and expression in RDS; comparison with other species. |journal=Exp. Lung Res. |volume=20 |issue= 1 |pages= 57–72 |year= 1994 |pmid= 8181452 |doi=
*cite journal | author=Nogee LM, Dunbar AE, Wert SE, "et al." |title=A mutation in the surfactant protein C gene associated with familial interstitial lung disease. |journal=N. Engl. J. Med. |volume=344 |issue= 8 |pages= 573–9 |year= 2001 |pmid= 11207353 |doi=
*cite journal | author=Glasser SW, Burhans MS, Korfhagen TR, "et al." |title=Altered stability of pulmonary surfactant in SP-C-deficient mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 11 |pages= 6366–71 |year= 2001 |pmid= 11344267 |doi= 10.1073/pnas.101500298
ee also
* Pulmonary_surfactant#Proteins
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