Reverse triiodothyronine

Reverse triiodothyronine

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ImageFile = Reverse triiodothyronine.png ImageSize = 200px
IUPACName = (2"S")-2-Amino-3- [4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl] propanoic acid
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Section1 = Chembox Identifiers
CASNo = 5817-39-0
PubChem = 22069
SMILES = C1=CC(=C(C=C1C [C@@H] (C(=O)O)N)I)OC2=CC(=C(C(=C2)I)O)I
MeSHName = Reverse+triiodothyronine
Section2 = Chembox Properties
Formula = C15H12I3NO4
MolarMass = 650.974
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Section3 = Chembox Hazards
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Reverse triiodothyronine (reverse T3, or rT3) is a molecule which is an isomer of triiodothyronine (T3). It is derived from thyroxine (T4) through the use of deiodinase.

rT3, unlike T3, does not stimulate thyroid hormone receptors. However, rT3 nonetheless binds to these receptors, thereby blocking the action of T3. Under stress conditions, the adrenal glands produce excess amounts of cortisol. Cortisol inhibits the conversion of T4 to T3, thus shunting T4 conversion from T3 towards rT3. Consequently, there is a widespread shutdown in T3 binding across the body. This condition is termed "Reverse T3 Dominance". It results in reduced body temperature, which slows the action of many enzymes, leading to a clinical syndrome, "Multiple Enzyme Dysfunction", which produces the effects seen in hypothyroidism. Effects include: fatigue, headache, migraine, PMS, irritability, fluid retention, anxiety and panic.

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External links

* [http://knoxintegrativemed.com/wilson's%20syndrome.htm Overview of Reverse T3 Dominance]


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