StRNA

Small Temporal RNA or stRNA regulate gene expression during roundworm development by preventing the mRNAs they bind to being translated. [Science, vol. 293, no. 5531, pp. 811-813 (August 3, 2001).] In contrast to siRNA downregulate expression of target RNAs after translation initiation without affecting mRNA stability [cite journal |url=http://www.jcb.org/cgi/content/full/156/1/17 |author=Grosshans H, Slack FJ |journal=J Cell Biol | title=Micro-RNAs : small is plentiful |year=2002 |volume=156 |pages=17–22] .

stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3' untranslated regions of their target genes. stRNAs are transcribed as longer precursor RNAs that are processed by the RNase Dicer/DCR-1 and members of the RDE-1/AGO1 family of proteins, which are better known for their roles in RNA interference (RNAi). stRNAs may function to control temporal identity during development in "C. elegans" and other organisms. [cite journal |author=Banerjee D, Slack F |title=Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression |journal=Bioessays |volume=24 |issue=2 |pages=119–29 |year=2002 |month=February |pmid=11835276 |doi=10.1002/bies.10046]

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