Ink4

Ink4

INK4 is a tumour suppressor protein. It is associated with several genes, including p16INK4a and p14ARF, and with several other proteins, like HRAS. [ [http://www.nature.com/nature/journal/v440/n7084/abs/nature04585.html Oncogenic activity of Cdc6 through repression of the INK4/ARF locus : Nature ] ] Lack of this protein has been associated with several types of cancer, including bladder and melanoma. The 'INK4' label is given to three proteins: INK4A and INK4B. These proteins act to inhibit cdk4 and cdk6 upon binding, causing the arrest of the cell cycle in G1. [ [http://www.chemistry.ohio-state.edu/~tsai/tumor_suppressor.htm INK4 Tumor Suppressor Proteins in the CDK4 ] ]

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