SOS1

Son of sevenless homolog 1 (Drosophila), also known as SOS1, is a human gene. PBB_Summary
section_title =
summary_text = RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). The first exchange factor to be identified for RAS was the S. cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the 'son of sevenless' gene (Sos) contains a domain that shows sequence similarity with the catalytic domain of CDC25. Sos may act as a positive regulator of RAS by promoting guanine nucleotide exchange. [supplied by OMIM] [cite web | title = Entrez Gene: SOS1 son of sevenless homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6654| accessdate = ] Recent studies also show that mutations in Sos1 can cause Noonan syndrome.

ee also

* Son of Sevenless

References

External links

* http://www.noonansyndrome.org
* http://ghr.nlm.nih.gov/gene=sos1

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lioubin MN, Myles GM, Carlberg K, "et al." |title=Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells. |journal=Mol. Cell. Biol. |volume=14 |issue= 9 |pages= 5682–91 |year= 1994 |pmid= 7520523 |doi=
*cite journal | author=Nel AE, Gupta S, Lee L, "et al." |title=Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR. |journal=J. Biol. Chem. |volume=270 |issue= 31 |pages= 18428–36 |year= 1995 |pmid= 7629168 |doi=
*cite journal | author=Pandey P, Kharbanda S, Kufe D |title=Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein. |journal=Cancer Res. |volume=55 |issue= 18 |pages= 4000–3 |year= 1995 |pmid= 7664271 |doi=
*cite journal | author=Hu Q, Milfay D, Williams LT |title=Binding of NCK to SOS and activation of ras-dependent gene expression. |journal=Mol. Cell. Biol. |volume=15 |issue= 3 |pages= 1169–74 |year= 1995 |pmid= 7862111 |doi=
*cite journal | author=Puil L, Liu J, Gish G, "et al." |title=Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. |journal=EMBO J. |volume=13 |issue= 4 |pages= 764–73 |year= 1994 |pmid= 8112292 |doi=
*cite journal | author=Webb GC, Jenkins NA, Largaespada DA, "et al." |title=Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively. |journal=Genomics |volume=18 |issue= 1 |pages= 14–9 |year= 1994 |pmid= 8276400 |doi= 10.1006/geno.1993.1421
*cite journal | author=Li N, Batzer A, Daly R, "et al." |title=Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. |journal=Nature |volume=363 |issue= 6424 |pages= 85–8 |year= 1993 |pmid= 8479541 |doi= 10.1038/363085a0
*cite journal | author=Chardin P, Camonis JH, Gale NW, "et al." |title=Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. |journal=Science |volume=260 |issue= 5112 |pages= 1338–43 |year= 1993 |pmid= 8493579 |doi=
*cite journal | author=Sadoshima J, Izumo S |title=The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. |journal=EMBO J. |volume=15 |issue= 4 |pages= 775–87 |year= 1996 |pmid= 8631299 |doi=
*cite journal | author=Feng GS, Ouyang YB, Hu DP, "et al." |title=Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. |journal=J. Biol. Chem. |volume=271 |issue= 21 |pages= 12129–32 |year= 1996 |pmid= 8647802 |doi=
*cite journal | author=Okada S, Pessin JE |title=Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor. |journal=J. Biol. Chem. |volume=271 |issue= 41 |pages= 25533–8 |year= 1996 |pmid= 8810325 |doi=
*cite journal | author=Corbalan-Garcia S, Yang SS, Degenhardt KR, Bar-Sagi D |title=Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5674–82 |year= 1996 |pmid= 8816480 |doi=
*cite journal | author=Sattler M, Salgia R, Shrikhande G, "et al." |title=Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1). |journal=J. Biol. Chem. |volume=272 |issue= 22 |pages= 14320–6 |year= 1997 |pmid= 9162067 |doi=
*cite journal | author=Leprince C, Romero F, Cussac D, "et al." |title=A new member of the amphiphysin family connecting endocytosis and signal transduction pathways. |journal=J. Biol. Chem. |volume=272 |issue= 24 |pages= 15101–5 |year= 1997 |pmid= 9182529 |doi=
*cite journal | author=Kouhara H, Hadari YR, Spivak-Kroizman T, "et al." |title=A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. |journal=Cell |volume=89 |issue= 5 |pages= 693–702 |year= 1997 |pmid= 9182757 |doi=
*cite journal | author=Chin H, Saito T, Arai A, "et al." |title=Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 2 |pages= 412–7 |year= 1997 |pmid= 9344843 |doi= 10.1006/bbrc.1997.7480
*cite journal | author=Zheng J, Chen RH, Corblan-Garcia S, "et al." |title=The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains. |journal=J. Biol. Chem. |volume=272 |issue= 48 |pages= 30340–4 |year= 1997 |pmid= 9374522 |doi=
*cite journal | author=Li S, Kim M, Hu YL, "et al." |title=Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. |journal=J. Biol. Chem. |volume=272 |issue= 48 |pages= 30455–62 |year= 1997 |pmid= 9374537 |doi=
*cite journal | author=Qian X, Vass WC, Papageorge AG, "et al." |title=N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 771–8 |year= 1998 |pmid= 9447973 |doi=
*cite journal | author=Curto M, Frankel P, Carrero A, Foster DA |title=Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 2 |pages= 555–60 |year= 1998 |pmid= 9480847 |doi= 10.1006/bbrc.1997.7982

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