MRAS

Muscle RAS oncogene homolog, also known as MRAS, is a human gene.cite web | title = Entrez Gene: MRAS muscle RAS oncogene homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22808| accessdate = ]

PBB_Summary
section_title =
summary_text = Members of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors. [supplied by OMIM] cite web | title = Entrez Gene: MRAS muscle RAS oncogene homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22808| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Matsumoto K, Asano T, Endo T |title=Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton. |journal=Oncogene |volume=15 |issue= 20 |pages= 2409–17 |year= 1997 |pmid= 9395237 |doi= 10.1038/sj.onc.1201416
*cite journal | author=Kimmelman A, Tolkacheva T, Lorenzi MV, "et al." |title=Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution. |journal=Oncogene |volume=15 |issue= 22 |pages= 2675–85 |year= 1998 |pmid= 9400994 |doi= 10.1038/sj.onc.1201674
*cite journal | author=Quilliam LA, Castro AF, Rogers-Graham KS, "et al." |title=M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 23850–7 |year= 1999 |pmid= 10446149 |doi=
*cite journal | author=Louahed J, Grasso L, De Smet C, "et al." |title=Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones. |journal=Blood |volume=94 |issue= 5 |pages= 1701–10 |year= 1999 |pmid= 10477695 |doi=
*cite journal | author=Ehrhardt GR, Leslie KB, Lee F, "et al." |title=M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line. |journal=Blood |volume=94 |issue= 7 |pages= 2433–44 |year= 1999 |pmid= 10498616 |doi=
*cite journal | author=Kimmelman AC, Osada M, Chan AM |title=R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells. |journal=Oncogene |volume=19 |issue= 16 |pages= 2014–22 |year= 2000 |pmid= 10803462 |doi= 10.1038/sj.onc.1203530
*cite journal | author=Rebhun JF, Castro AF, Quilliam LA |title=Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34901–8 |year= 2001 |pmid= 10934204 |doi= 10.1074/jbc.M005327200
*cite journal | author=Gao X, Satoh T, Liao Y, "et al." |title=Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 42219–25 |year= 2001 |pmid= 11524421 |doi= 10.1074/jbc.M105760200
*cite journal | author=Ortiz-Vega S, Khokhlatchev A, Nedwidek M, "et al." |title=The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. |journal=Oncogene |volume=21 |issue= 9 |pages= 1381–90 |year= 2002 |pmid= 11857081 |doi= 10.1038/sj.onc.1205192
*cite journal | author=Kimmelman AC, Nuñez Rodriguez N, Chan AM |title=R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade. |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5946–61 |year= 2002 |pmid= 12138204 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Mitin NY, Ramocki MB, Zullo AJ, "et al." |title=Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22353–61 |year= 2004 |pmid= 15031288 |doi= 10.1074/jbc.M312867200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Roberts AE, Araki T, Swanson KD, "et al." |title=Germline gain-of-function mutations in SOS1 cause Noonan syndrome. |journal=Nat. Genet. |volume=39 |issue= 1 |pages= 70–4 |year= 2007 |pmid= 17143285 |doi= 10.1038/ng1926
*cite journal | author=Yoshikawa Y, Satoh T, Tamura T, "et al." |title=The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes. |journal=Mol. Biol. Cell |volume=18 |issue= 8 |pages= 2949–59 |year= 2007 |pmid= 17538012 |doi= 10.1091/mbc.E07-03-0250

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