- Metallopanstimulin
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Metallopanstimulin or "MPS" is a zinc finger protein proposed to be involved DNA repair as well as oncogenesis.[1] Its expression is increased in several types of malignancy and MPS levels have been reported to drop with treatment of some cancers. It has also been used as a target for some chemotherapies, which aim to chelate out the zinc from the zinc finger motif of the MPS, thus yielding it inactive. These therapies have shown promise for the treatment of cancer in laboratory experiments and some limited clinical trials. Head and neck cancer transfected to overexpress this protein have demonstrated suppressed growth.
References
- ^ Fernandez-Pol JA. "Metallopanstimulin as a novel tumor marker in sera of patients with various types of common cancers: implications for prevention and therapy" Anticancer Research 1996 Jul-Aug;16, pp. 2177-85.
- Scurry WC Jr, Stack BC Jr. (December 2007). "Role of metalloproteins in the clinical management of head and neck squamous cell carcinoma". Head Neck 29 (12): 1144–55. doi:10.1002/hed.20655. PMID 17657798.
- Stack BC Jr, Hollenbeak CS, Lee CM, Dunphy FR, Lowe VJ, Hamilton PD (December 2004). "Metallopanstimulin as a marker for head and neck cancer". World J Surg Oncol 14: 2:45. doi:10.1186/1477-7819-2-45. PMC 544581. PMID 15598348. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=544581.
- Lee WJ, Keefer K, Hollenbeak CS, Stack BC Jr. (October 2004). "A new assay to screen for head and neck squamous cell carcinoma using the tumor marker metallopanstimulin". Otolaryngol Head Neck Surg 131 (4): 466–71. doi:10.1016/j.otohns.2004.03.011. PMID 15467619.
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