Bronchorrhea

Bronchorrhea is the production of more than 100 mL per day of watery sputum.cite journal |author=Lembo T, Donnelly T |title=A case of pancreatic carcinoma causing massive bronchial fluid production and electrolyte abnormalities |journal=Chest |volume=108 |issue=4 |pages=1161–3 |year=1995 |pmid=7555132 |doi=10.1378/chest.108.4.1161] Chronic bronchitis is a common cause, but it may also be caused by asthma,cite journal |author=Shimura S, Sasaki T, Sasaki H, Takishima T |title=Chemical properties of bronchorrhea sputum in bronchial asthma |journal=Chest |volume=94 |issue=6 |pages=1211–5 |year=1988 |pmid=2903819 |doi=10.1378/chest.94.6.1211] pulmonary contusion,cite journal |author=Gavelli G, Canini R, Bertaccini P, Battista G, Bnà C, Fattori R |title=Traumatic injuries: imaging of thoracic injuries |journal=European Radiology |volume=12 |issue=6 |pages=1273–1294 |year=2002 |month=June |pmid=12042932 |doi=10.1007/s00330-002-1439-6 |url=] bronchiectasis, tuberculosis, cancer, scorpion stings, and poisoning by organophosphates and other poisons. Massive bronchorrhea may occur in either bronchioloalveolar cancer, or in metastatic cancer that is growing in a bronchioloalveolar pattern.cite journal |author=Shimura S, Takishima T |title=Bronchorrhea from diffuse lymphangitic metastasis of colon carcinoma to the lung |journal=Chest |volume=105 |issue=1 |pages=308–10 |year=1994 |pmid=8275762 |doi=10.1378/chest.105.1.308] cite journal |author=Mito K, Yamakami Y, Kashima K, Mizunoe S, Tokimatsu I, Ichimiya T, Hiramatsu K, Nagai H, Kadota J, Nasu M |title= [A case of suspected lung metastasis of pancreatic carcinoma with bronchorrhea similar to bronchioloalveolar carcinoma] |journal=Nihon Kokyuki Gakkai Zasshi |volume=40 |issue=8 |pages=666–70 |year=2002 |pmid=12428395]

Treatment

Treatment options include
* gefitinib - epidermal growth factor receptor tyrosine kinase inhibitor cite journal |author=Kitazaki T, Soda H, Doi S, Nakano H, Nakamura Y, Kohno S |title=Gefitinib inhibits MUC5AC synthesis in mucin-secreting non-small cell lung cancer cells |journal=Lung Cancer |volume=50 |issue=1 |pages=19–24 |year=2005 |pmid=16009452 |doi=10.1016/j.lungcan.2005.05.005] cite journal |author=Kitazaki T, Fukuda M, Soda H, Kohno S |title=Novel effects of gefitinib on mucin production in bronchioloalveolar carcinoma; two case reports |journal=Lung Cancer |volume=49 |issue=1 |pages=125–8 |year=2005 |pmid=15949598 |doi=10.1016/j.lungcan.2004.11.027] cite journal |author=Milton D, Kris M, Gomez J, Feinstein M |title=Prompt control of bronchorrhea in patients with bronchioloalveolar carcinoma treated with gefitinib (Iressa) |journal=Support Care Cancer |volume=13 |issue=1 |pages=70–2 |year=2005 |pmid=15558327 |doi=10.1007/s00520-004-0717-z] cite journal |author= |title=Successful treatment of persistent bronchorrhea by gefitinib in a case with Recurrent Bronchioloalveolar Carcinoma: a case report |journal=World J Surg Oncol |volume=1 |issue=1 |pages=8 |year=2003 |pmid=12917017|doi=10.1186/1477-7819-1-8] cite journal |author=Yano S, Kanematsu T, Miki T, Aono Y, Azuma M, Yamamoto A, Uehara H, Sone S |title=A report of two bronchioloalveolar carcinoma cases which were rapidly improved by treatment with the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 ("Ijournal=Cancer Sci |volume=94 |issue=5 |pages=453–8 |year=2003 |pmid=12824893]
* indomethacincite journal |author=Tamaoki J, Kohri K, Isono K, Nagai A |title=Inhaled indomethacin in bronchorrhea in bronchioloalveolar carcinoma: role of cyclooxygenase |journal=Chest |volume=117 |issue=4 |pages=1213–4 |year=2000 |pmid=10767270 |doi=10.1378/chest.117.4.1213] cite journal |author=Homma S, Kawabata M, Kishi K, Tsuboi E, Narui K, Nakatani T, Nakata K |title=Successful treatment of refractory bronchorrhea by inhaled indomethacin in two patients with bronchioloalveolar carcinoma |journal=Chest |volume=115 |issue=5 |pages=1465–8 |year=1999 |pmid=10334175 |doi=10.1378/chest.115.5.1465] cite journal |author=Tamaoki J, Chiyotani A, Kobayashi K, Sakai N, Kanemura T, Takizawa T |title=Effect of indomethacin on bronchorrhea in patients with chronic bronchitis, diffuse panbronchiolitis, or bronchiectasis |journal=Am Rev Respir Dis |volume=145 |issue=3 |pages=548–52 |year=1992 |pmid=1546834]
* corticosteroidscite journal |author=Nakajima T, Terashima T, Nishida J, Onoda M, Koide O |title=Treatment of bronchorrhea by corticosteroids in a case of bronchioloalveolar carcinoma producing CA19-9 |journal=Intern Med |volume=41 |issue=3 |pages=225–8 |year=2002 |pmid=11929186 |doi=10.2169/internalmedicine.41.225]
* octreotidecite journal |author=Hudson E, Lester J, Attanoos R, Linnane S, Byrne A |title=Successful treatment of bronchorrhea with octreotide in a patient with adenocarcinoma of the lung |journal=J Pain Symptom Manage |volume=32 |issue=3 |pages=200–2 |year=2006 |pmid=16939841 |doi=10.1016/j.jpainsymman.2006.05.003]
* radiation therapycite journal |author=Krawtz S, Mehta A, Vijayakumar S, Stoller J |title=Palliation of massive bronchorrhea |journal=Chest |volume=94 |issue=6 |pages=1313–4 |year=1988 |pmid=2461277]

References