Glycolipid transfer protein
- Glycolipid transfer protein
Pfam_box
Symbol = GLTP
Name = Glycolipid transfer protein (GLTP)
width =
caption =
Pfam= PF08718
InterPro= IPR014830
SMART=
Prosite =
SCOP =
TCDB =
OPM family= 92
OPM protein= 1swx
PDB=PDB3|1swxA:6-207 PDB3|2evtA:6-207 PDB3|1sx6A:6-207PDB3|1wbeA:6-207 PDB3|2bv7A:6-207 PDB3|1tfjA:6-207
Glycolipid transfer protein is a cytosolic protein that catalyses the transfer of glycolipids between different intracellular membranes. [cite journal |author=Brown RE, Lin X, Rao CS, Pike HM, Molotkovsky JG |title=Glycolipid transfer protein mediated transfer of glycosphingol ipids between membranes: a model for action based on kinetic and thermodynamic analyses |journal=Biochemistry |volume=43 |issue=43 |pages=- |year=2004 |pmid=15504043 |doi=10.1021/bi0492197] ][cite journal |author=Nymalm Y, Airenne TT, Kidron H, Salminen TA, Nylund M, West G, Mattjus P |title=Structural evidence for adaptive ligand binding of glycolipid transfer protein |journal=J. Mol. Biol. |volume=355 |issue=2 |pages=- |year=2006 |pmid=16309699] .]This protein transport primarily different glycosphingolipids and glyceroglycolipids between intracellular membranes, but not phospholipids. It might be also involved in translocation of glucosylceramides. It was found in brain, kidney, spleen, lung, cerebellum, liver and heart.
Human proteins containing this domain
GLTP; PLEKHA8; PLEKHA9;
References
External links
* [http://www.ebi.uniprot.org/entry/P68265 Uniprot entry]
* [http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF08718 Pfam entry]
* - Calculated spatial position of Glycolipid transfer protein in membrane
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