Hydropathy index

Hydropathy index

The hydropathy index of an amino acid is a number representing the hydrophobic or hydrophilic properties of its side-chain. It was proposed in 1982 by Jack Kyte and Russell F. Doolittle. []

The larger the number is, the more hydrophobic the amino acid. The most hydrophobic amino acids are isoleucine (4.5) and valine (4.2). The most hydrophilic ones are arginine (-4.5) and lysine (-3.9). This is very important in protein structure; hydrophobic amino acids tend to be internal (with regard to the protein's 3 dimensional shape) while hydrophilic amino acids are more commonly found towards the protein surface.

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