Historadiography

Historadiography

Historadiography is a technique formerly utilized in the fields of histology and cellular biology to provide semiquantitative information regarding the density of a tissue sample. It is usually synonymous with microradiography. [cite web|url=http://cancerweb.ncl.ac.uk/cgi-bin/omd?historadiography|title=CancerWeb Online Medical Dictionary] This is achieved by layering a ground section of mineralized tissue (such as bone) with photographic emulsion on a glass slide and exposing the sample to a beam of X-rays. After developing the emulsion, the resulting radiograph can be viewed with a microscope. A side-by-side comparison with a slide containing radiographs of various substances of known mass can provide a rough mass estimate, and therefore a rough approximation of the concentration of calcium salts in the sample.

Historadiography has also been used to visualize staining of tissue, such as spinal cord samples with thorotrast, which contains thorium that is opaque to X-rays. [cite web|url=http://www.ajronline.org/cgi/content/abstract/118/4/923|title=CONTACT HISTORADIOGRAPHY OF NERVOUS TISSUE IMPREGNATED WITH THOROTRAST|author=F. P. BOHATIRCHUK , T. F. JELETZKY , and L. P. IVAN|date=1973]

Over recent decades researchers have generally lost interest in historadiography. The most recent publication using the term (1998) to be indexed in PubMed [cite web|url=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=historadiography|title=PubMed search: historadiography] referred to autoradiography of tritium incorporated in thymidine. [PMID 9555564]

References


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  • historadiography — noun the radiography of soft tissue using long wavelength X rays of low penetrating power …   Wiktionary

  • historadiography — Radiography of tissue, specifically microscopic sections; usually microradiography. * * * his·to·ra·di·og·ra·phy .his tō .rā dē äg rə fē n, pl phies microradiography of plant or animal tissue his·to·ra·dio·graph·ic dē ə graf ik adj * * …   Medical dictionary

  • microradiography — Making radiographs of histologic sections of tissue for enlargement. SEE ALSO: historadiography. * * * mi·cro·ra·di·og·ra·phy .rā dē äg rə fē n, pl phies radiography in which an X ray photograph is prepared showing minute internal structure see… …   Medical dictionary

  • Histology — Not to be confused with Historiography. A stained histologic specimen, sandwiched between a glass microscope slide and coverslip, mounted on the stage of a light microscope …   Wikipedia

  • Autoradiograph — An autoradiograph is an image on an x ray film or nuclear emulsion produced by the pattern of decay emissions (e.g., beta particles or gamma rays) from a distribution of a radioactive substance. Alternatively, the autoradiograph can also be… …   Wikipedia

  • Thorotrast — is a suspension containing particles of the radioactive compound thorium dioxide, ThO2, used as a contrast medium in X ray diagnostics in the 1930s and 40s (use in some countries, such as the U.S., continued into the 1950s [… …   Wikipedia

  • Histologie — L’histologie (du grec ancien ἱστός tissu et λόγος discours) est la branche de la biologie et de la médecine qui étudie les tissus biologiques. Elle est à mi chemin entre la biologie cellulaire, l anatomie, la biochimie et la physiologie. On… …   Wikipédia en Français

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