type = mab

source = murine monoclonal antibody
target = ovarian cancer cells expressing CA-125
CAS_number = 792921-10-9
ATC_prefix = L
ATC_suffix = 03AX
ATC_supplemental =
PubChem =
DrugBank =
molecular_weight = N/A
bioavailability = not available (N/A)
protein_bound =
metabolism = N/A
elimination_half-life = N/A
excretion = N/A
pregnancy_AU =
pregnancy_US =
pregnancy_category = N/A
legal_AU =
legal_UK =
legal_US =
legal_status = under clinical development
routes_of_administration = subcutaneous

Abagovomab is a mouse anti-idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen (CA-125) highly expressed in the epithelial ovarian cancer. Abagovomab does not bind directly to CA-125, but it works as a "surrogate" antigen, enabling the immune system to identify and attack tumour cells displaying the CA 125 protein. Through this, it is hoped that the body's immune system may be able to combat any remaining individual tumour cells and thus prevent recurrence of the disease.

Current Status

Abagovomab is currently under clinical development in patients with advanced ovarian cancer, as consolidation of the remission status obtained following surgery and standard platinum and taxane first line chemotherapy.

Phase II

In a Phase II study on 119 patients with advanced ovarian cancer in which the standard therapies had already been ineffective, treatment with abagovomab led to a prolongation of survival time (23.4 months compared to 4.9 months) in those patients who responded to the vaccination, i.e. those in whom the formation of antibodies against the tumour was proven (almost 70 % of patients).The vaccine showed hardly any side effects in preliminary studies.

Ovarian Cancer

Ovarian cancer is the most malignant tumour of the female reproductive organs. After endometrial cancer, it is the second most common genital tumour in women with approximately 9,000 women newly affected each year and, because of its aggressiveness, it has the highest mortality rate. This is due in part to the fact that there is no screening examination for early detection, and that the disease is therefore usually only discovered at an advanced stage, and in part to the tumour's tendency, although responding well to initial treatment, to recur again later.

In spite of initially successful treatment with surgery and chemotherapy, which forces back the tumour "completely", i.e. into no longer visible residues, there is a relapse of the disease (recurrence) in more than half the women affected. Today, no further therapy would be conducted in this situation as long as the disease did not occur again, i.e. clinical monitoring of the symptom-free patients as part of follow-up care is the current standard procedure. In this time-window of the patient’s hystory so called ‘watch and wait’ abagovomab is potentially capable of deferring or even preventing the occurrence of the relapse.


Abagovomab has been developed by the pharmaceutical company Menarini. A multicenter clinical trial, internationally known as MIMOSA (Monoclonal antibody Immunotherapy for Malignancies of the Ovary by Subcutaneous Abagovomab), in which Abagovomab will be administered as maintenance therapy (after first line therapy with surgery and chemotherapy), is ongoing in patients with ovarian cancer.Nine hundred women in whom the ovarian tumour was removed by surgery and standard chemotherapy with paclitaxel und carboplatin can be enrolled in the MIMOSA study, involving eight countries throughout the world (Germany, USA, Italy, Poland, Czech Republic, Spain, Hungary and Belgium) in more than 120 experienced clinical sites.

Further reading

* Wagner U, Kohler S, Reinartz S, Giffels P, Huober J, Renke K, Schlebusch H, Biersack HJ, Mobus V, Kreienberg R, Bauknecht T, Krebs D, Wallwiener D. Immunological consolidation of ovarian carcinoma recurrences with monoclonal anti-idiotype antibody ACA125: immune responses and survival in palliative treatment. Clin Cancer Res. 2001;7(5):1154-62. http://clincancerres.aacrjournals.org/cgi/content/full/7/5/1154

* Reinartz S, Kohler S, Schlebusch H, Krista K, Giffels P, Renke K, Huober J, Mobus V, Kreienberg R, DuBois A, Sabbatini P, Wagner U. Vaccination of patients with advanced ovarian carcinoma with the anti-idiotype ACA125: immunological response and survival (phase Ib/II). Clin Cancer Res. 2004;10(5):1580-7. http://clincancerres.aacrjournals.org/cgi/content/full/10/5/1580

* Pfisterer J, du Bois A, Sehouli J, Loibl S, Reinartz S, Reuß A, Canzler U, Belau A, Jackisch C, Kimmig R, Wollschlaeger K, Heilmann V, Hilpert F. The anti-idiotypic antibody abagovomab in patients with recurrent ovarian cancer. A phase I trial of the AGO-OVAR. Ann Oncol. 2006;17(10):1568-77. http://annonc.oxfordjournals.org/cgi/content/abstract/17/10/1568

* Sabbatini P, Dupont J, Aghajanian C, Derosa F, Poynor E, Anderson S, Hensley M, Livingston P, Iosonos A, Spriggs D, McGuire W, Reinartz S, Schneider S, Grande C, Lele S, Rodabaugh K, Kepner J, Ferrone S, Odunsi K. Phase I study of abagovomab in patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer. Clin Cancer Res. 2006;12(18):5503-10. http://clincancerres.aacrjournals.org/cgi/content/abstract/12/18/5503

External links

* [http://www.menarini.com/english/ricerca_sviluppo/abagovomab.htm Menarini page about abagovomab]
* [http://www.menarini.com/english/mimosa.htm Menarini page about MIMOSA project]
* [http://www.clinicaltrials.gov/ct/show/NCT00418574?order=1 Clinical trial MIMOSA]
* [http://www.mskcc.org/mskcc/html/2270.cfm?TAB=All&IRBNO=06-144&SelectedDisease=All Clinical trial MIMOSA]

Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • abagovomab — noun A particular monoclonal antibody …   Wiktionary

  • Monoclonal antibodies — A general representation of the methods used to produce monoclonal antibodies. Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique… …   Wikipedia

  • Cetuximab — ? Monoclonal antibody Type Whole antibody Source Chimeric (mouse/human) Target EGF receptor Clinical data AHFS/Drugs.com …   Wikipedia

  • Gemtuzumab ozogamicin — ? Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target CD33 Clinical data Trade names Mylotarg AHFS/ …   Wikipedia

  • Oregovomab — ? Monoclonal antibody Type Whole antibody Source Mouse Target CA125 Clinical data Pregnancy cat.  ? Legal status  ? …   Wikipedia

  • Anatumomab mafenatox — ? Monoclonal antibody Type Fab fragment Source Mouse Target TAG 72 Clinical data Pregnancy cat.  ? Legal status  ? …   Wikipedia

  • Bivatuzumab mertansine — ? Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target CD44 v6 …   Wikipedia

  • Cantuzumab mertansine — ? Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target MUC1 …   Wikipedia

  • Matuzumab — ? Monoclonal antibody Type Whole antibody Source Humanized Target EGFR Clinical data Pregnancy cat.  ? Legal status clinical develop …   Wikipedia

  • Nimotuzumab — ? Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target EGFR Clinical data Pregnancy cat.  ? Legal status …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”