Indirect pathway of movement
- Indirect pathway of movement
Indirect pathway of movement describes the one of the pathways modulated by the striatum, the other being a direct pathway of movement.
In the indirect pathway, striatal neurons activate the neurons in the globus pallidus externus Releasing GABA, which in turn inactivate neurons in the subthalamic nucleus. This nucleus, now inactivated, can not inhibit the inhibition that the globus pallidus internus will place on the thalamus - thus leading to no cortical stimulation via the pathways of the thalamus. *** Opposite of the direct pathway, globus pallidus internus neurons inhibit thalamic neurons that excite the premotor cortex via a double inhibition effect.***
The result of all these excitations and inhibitions is an inhibition of movement by the indirect pathway. This is why damage to the pathway, as in Parkinson's disease, causes an inability to switch to new, desired motor programs. A hypo-kinetic effect (opposite effect of huntingtons corea - a hyperkinetic effect).
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