Smart gene

Smart gene

A smart gene is an artificially constructed genetic molecule (known as a "construct") composed of one or more genes encoding a protein to be expressed and a region (such as a promoter) that will only allow the protein to be expressed under specific conditions (such as the presence of a particular molecule).Failed verification|date=September 2008 Therefore a smart gene allows "conditional" expression of the gene it encodes for based on whether specific conditions inside the cell are met. This property makes such constructs as ideal therapeutic vehicles for gene therapy.

Using combinations of smart gene constructs a DNA computer has been designed that is able to trigger gene expression based on the presence of a particular mRNA molecule.Failed verification|date=September 2008 Consequently by employing chains of such constructs more sophisticated decision making systems can be produced.

External links

* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15116117 An autonomous molecular computer for logical control of gene expression] (PubMed)
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15215499 Stochastic computing with biomolecular automata] (PubMed)


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