Organophosphate-induced delayed neuropathy

Organophosphate-induced delayed neuropathy (OPIDN), also called organophosphate-induced delayed polyneuropathy (OPIDP), is a neuropathy caused by killing of neurons in the central nervous system, especially in the spinal cord, as a result of acute or chronic organophosphate poisoning.

A striking example of OPIDN occurred during the 1930s Prohibition Era when thousands of men in the American South and Midwest developed arm and leg weakness and pain after drinking a "medicinal" alcohol substitute. The drink, called "Ginger Jake," contained an adulterated Jamaican ginger extract containing tri-ortho-cresyl phosphate (TOCP) which resulted in partially reversible neurologic damage. The damage resulted in the limping "Jake Leg" or "Jake Walk" which were terms frequently used in the blues music of the period. Europe and Morocco both experienced outbreaks of TOCP poisoning from contaminated abortifacients and cooking oil, respectively.^[1]

OPIDN can be induced by diisopropylfluorophosphate, which is used for this purpose as an experimental agent.

References

1. ^ Morgan (1978); Segalla, Spencer (2011), "The 1959 Moroccan Oil Poisoning and US Cold War Disaster Diplomacy," Journal of North African Studies. Available online at http://dx.doi.org/10.1080/13629387.2011.610118

External links

• Current issues in organophosphate toxicology

This Toxicology-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Organophosphates Neurological disorders Toxic effects of substances chiefly nonmedicinal as to source Toxicology stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Ramona Quimby Schucker yachts Look at other dictionaries: Neuropathy (disambiguation) — Neuropathy usually refers to peripheral neuropathy, which denotes damage to nerves of the peripheral nervous system. Neuropathy may also refer to: Cranial neuropathy, any condition affecting cranial nerves Auditory neuropathy, any condition… …   Wikipedia Neuropathy target esterase — Patatin like phospholipase domain containing 6 Identifiers Symbols PNPLA6; NTE; NTEMND; SPG39; sws External IDs …   Wikipedia Organophosphate poisoning — Classification and external resources Phosphoric acid ICD 10 T …   Wikipedia OPIDN — organophosphate induced delayed neuropathy …   Medical dictionary OPIDN — • organophosphate induced delayed neuropathy …   Dictionary of medical acronyms & abbreviations Dimefox — IUPAC name N [dimethylamino(fluoro)phosphoryl] N methylmethanamine …   Wikipedia Jamaican ginger — Extract (known in the United States by the slang name Jake) was an early 20th century patent medicine that provided a convenient way to bypass Prohibition laws, since it contained between 70 80% ethanol by weight.Jake was not itself dangerous,… …   Wikipedia Monocrotophos — IUPAC name Dimethyl (E) 1 methyl 2 (methylcarbamoyl)vinyl phosphate …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”