Despair may refer to:
- Despair (emotion), hopelessness or lack of hope
- Despair (novel), a 1936 novel by Vladimir Nabokov
- Despair (film), a 1978 film adapted from the above and directed by Rainer Fassbinder
- Despair, Inc., a company that makes satirical posters and souvenirs
- Despair (band), a thrash metal band
- Despair (DC Comics), a character in the Sandman comic book series
- Despair (album), an album by Omar Rodríguez-López
- Mount Despair (Washington), a mountain in the North Cascades National Park
- Giant Despair, a character in The Pilgrim's Progress by John Bunyan
- The Sickness Unto Death, an 1849 philosophical work on despair by philosopher Søren Kierkegaard
This disambiguation page lists articles associated with the same title.
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