Brevetoxin

Brevetoxin

Brevetoxin (PbTx), or brevetoxins, are a suite of cyclic polyether compounds produced naturally by a species of dinoflagellate known as "Karenia brevis". Brevetoxins are neurotoxins that bind to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes and causing the illness clinically described as Neurotoxic Shellfish Poisoning (NSP).

Other Brevetoxins:
*Brevetoxin-5 (PbTx-5): like PbTx-3, but acetylated hydroxyl group in position 38.
*Brevetoxin-6 (PbTx-6): like PbTx-2, but double bond 27-28 is epoxidated.

Brevetoxin-2 was synthesized in 1995 by K. C. Nicolaou and coworkers in 123 steps with 91% average yield (final yield ~9·10-6). [ [http://www.chemistry.msu.edu/courses/cem852/classics/Chapter37.pdf Microsoft PowerPoint - brevetoxin synthesis ] ]

References

See also

*Red tide
*Algal bloom
*Harmful algal bloom
*Karenia brevis


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  • Brevetoxin — Brevetoxine sind neurotoxische Algengifte des Dinoflagellaten Karenia brevis (früher Gymnodinium breve). Inhaltsverzeichnis 1 Vorkommen und Bedeutung 2 Struktur und Eigenschaften 3 Toxizität 4 Siehe auc …   Deutsch Wikipedia

  • Brevetoxin A — Brevetoxine sind neurotoxische Algengifte des Dinoflagellaten Karenia brevis (früher Gymnodinium breve). Inhaltsverzeichnis 1 Vorkommen und Bedeutung 2 Struktur und Eigenschaften 3 Toxizität 4 Siehe auc …   Deutsch Wikipedia

  • Brevetoxin B — Brevetoxine sind neurotoxische Algengifte des Dinoflagellaten Karenia brevis (früher Gymnodinium breve). Inhaltsverzeichnis 1 Vorkommen und Bedeutung 2 Struktur und Eigenschaften 3 Toxizität 4 Siehe auc …   Deutsch Wikipedia

  • brevetoxin — a neurotoxin produced by the dinoflagellate Karenia brevis which itself forms red tides (q.v.). Causes fish kills and illness in humans who ingest filter feeding shellfish …   Dictionary of ichthyology

  • brevetoxin — noun Any of a class of complex polycyclic polyethers that cause neurotoxic shellfish poisoning …   Wiktionary

  • brevetoxin — breve·tox·in (brevґə tok″sin) any of a group of lipid soluble neurotoxins found in the protozoan species Karenia brevis; they cause red tides, brevetoxicosis in marine mammals and birds, and neurotoxic shellfish poisoning in humans …   Medical dictionary

  • BTX-B — brevetoxin B …   Medical dictionary

  • HBT-B — brevetoxin B …   Medical dictionary

  • BTX-B — • brevetoxin B …   Dictionary of medical acronyms & abbreviations

  • HBT-B — • brevetoxin B …   Dictionary of medical acronyms & abbreviations

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