Peptidyl-glutamyl peptide-hydrolyzing activity

Peptidyl-glutamyl peptide-hydrolyzing activity

Peptidyl-glutamyl peptide-hydrolyzing (PGPH) enzyme activity is a means of proteolysis that cleaves peptide bonds in proteins immediately after acidic or branched-chain amino acids. One of the three catalytic β subunits of the proteasome has PGPH activity and is strongly inhibited by the proteasome inhibitor epoxomicin.Meng L, Mohan R, Kwok BHB, Elofsson M, Sin N, Crews CM. (1999). Epoxomicin, a potent and selective proteasome inhibitor, exhibits "in vivo" antiinflammatory activity. "Proc Natl Acad Sci USA" 96(18): 10403-10408.]

References

External links

* [http://db.yeastgenome.org/cgi-bin/GO/go.pl?goid=45024 Gene Ontology entry]


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  • Proteasome — Proteasomes are large protein complexes inside all eukaryotes and archaea, as well as in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm.cite journal |author=Peters JM, Franke WW, Kleinschmidt JA |title=Distinct 19 …   Wikipedia

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