Paracellular transport

Paracellular transport

Paracellular transport refers to the transfer of substances "between" cells of an epithelium. [ [http://www.citracal.com/gfx/dyk_absorption.gifDiagram at citracal.com] ] [Dorlands|t_16|14158724]

It is in contrast to "transcellular transport", where the substancees travel "through" the cell, passing through both the apical membrane and basolateral membrane. [ [http://www.trinity.edu/rblyston/MicroA/Lectures/L07pt2-html/sld022.htm Epithelial Transcellular Transport ] ] [GeorgiaPhysiology|1/1ch2/s1ch2_37] [http://www.mun.ca/biology/desmid/brian/BIOL2060/CellBiol11/CB11_19.html]

The distinction is in particular significance in renal physiology. Transcellular transport is more likely to involve energy expenditure than paracellular transport. [ [http://www.acbrown.com/renal/OutTubl.htm Tubular Transport ] ]

Capillaries of Blood Brain Barrier have transcellular transport only in contrast with normal capillaries which have both - transcellular and paracellular transport. This is due to the presence of tight junctions in Blood Brain Barrier and Astrocytes that surround the capillaries.

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