CLDN2

Claudin 2, also known as CLDN2, is a human gene.cite web | title = Entrez Gene: CLDN2 claudin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9075| accessdate = ] It belongs to the group of claudins.

PBB_Summary
section_title =
summary_text = Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002). [supplied by OMIM] cite web | title = Entrez Gene: CLDN2 claudin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9075| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kniesel U, Wolburg H |title=Tight junctions of the blood-brain barrier. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57–76 |year= 2000 |pmid= 10690502 |doi=
*cite journal | author=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport. |journal=Traffic |volume=2 |issue= 2 |pages= 93–8 |year= 2001 |pmid= 11247307 |doi=
*cite journal | author=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285–93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088
*cite journal | author=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531–6 |year= 2003 |pmid= 12231346 |doi=
*cite journal | author=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins. |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1–44 |year= 2003 |pmid= 12475568 |doi=
*cite journal | author=Furuse M, Fujita K, Hiiragi T, "et al." |title=Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. |journal=J. Cell Biol. |volume=141 |issue= 7 |pages= 1539–50 |year= 1998 |pmid= 9647647 |doi=
*cite journal | author=Morita K, Furuse M, Fujimoto K, Tsukita S |title=Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 511–6 |year= 1999 |pmid= 9892664 |doi=
*cite journal | author=Itoh M, Furuse M, Morita K, "et al." |title=Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1351–63 |year= 2000 |pmid= 10601346 |doi=
*cite journal | author=Sakaguchi T, Gu X, Golden HM, "et al." |title=Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21361–70 |year= 2002 |pmid= 11934881 |doi= 10.1074/jbc.M110261200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Colegio OR, Van Itallie C, Rahner C, Anderson JM |title=Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. |journal=Am. J. Physiol., Cell Physiol. |volume=284 |issue= 6 |pages= C1346–54 |year= 2003 |pmid= 12700140 |doi= 10.1152/ajpcell.00547.2002
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Mankertz J, Hillenbrand B, Tavalali S, "et al." |title=Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity. |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 4 |pages= 1001–7 |year= 2004 |pmid= 14751232 |doi=
*cite journal | author=Yamauchi K, Rai T, Kobayashi K, "et al." |title=Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 13 |pages= 4690–4 |year= 2004 |pmid= 15070779 |doi= 10.1073/pnas.0306924101
*cite journal | author=Escaffit F, Boudreau F, Beaulieu JF |title=Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. |journal=J. Cell. Physiol. |volume=203 |issue= 1 |pages= 15–26 |year= 2005 |pmid= 15389642 |doi= 10.1002/jcp.20189

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