Renal papillary necrosis

Infobox_Disease
Name = PAGENAME


Caption =
DiseasesDB = 9572
ICD10 = N17.2
ICD9 = ICD9|584.7
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj = med
eMedicineTopic = 2839
eMedicine_mult = eMedicine2|radio|523
MeshID = D007681

Renal papillary necrosis is a form of nephropathy involving the necrosis of the renal papilla,cite journal |author=Jung DC, Kim SH, Jung SI, Hwang SI, Kim SH |title=Renal papillary necrosis: review and comparison of findings at multi-detector row CT and intravenous urography |journal=Radiographics : a review publication of the Radiological Society of North America, Inc |volume=26 |issue=6 |pages=1827–36 |year=2006 |pmid=17102053 |doi=10.1148/rg.266065039 |url=http://radiographics.rsnajnls.org/cgi/pmidlookup?view=long&pmid=17102053] which is supplied by the vasa recta.

Causes

Analgesic nephropathy could be the most common cause of renal papillary necrosis. The damage is cumulative and most patients of renal papillary necrosis would have ingested at least 2kg of analgesics in the past. The risk is higher for phenacetin and acetaminophen compared to aspirin and other NSAIDs.

It is also caused by diabetes mellitus, in which it is related to renal infection or vascular disease. It can also occur as a result of acute pyelonephritis or sickle cell disease. Lastly, it can be an outcome of chronic analgesic nephritis, with persistent use or abuse of phenacetin or its derivatives (such as Acetaminophen). This is less common since phenacetin is no longer available over the counter.

References

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