Allan Maxam

Infobox Scientist
name = Allan Maxam
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doctoral_advisor = Walter Gilbert
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known_for = DNA sequencing
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Allan Maxam is one of the pioneers of molecular genetics. He was one of the contributors to develop a DNA sequencing method at Harvard University, while working as a student in the laboratory of Walter Gilbert [Citation
id = PMID:265521
url= http://www.ncbi.nlm.nih.gov/pubmed/265521
last=Maxam
first=A M
last2=Gilbert
first2=W
publication-date=1977 Feb
year=1977
title=A new method for sequencing DNA.
volume=74
issue=2
periodical=Proc. Natl. Acad. Sci. U.S.A.
pages=560-4] [ [http://nobelprize.org/nobel_prizes/chemistry/laureates/1980/gilbert-lecture.pdf DNA SEQUENCING AND GENE STRUCTURE, Walter Gilbert Nobel lecture, 8 December, 1980] ] .

Walter Gilbert and Allan Maxam developed a DNA sequencing method which combined chemicals that cut DNA only at specific bases with radioactive labeling and Southern blotting to determine the sequence of long DNA segments [Maxam AM, Gilbert W, Sequencing end-labeled DNA with base-specific chemical cleavages, Methods Enzymol. 1980;65(1):499-560] .

References

* Gilbert, Walter and Maxam. Allan, The Nuclcotide Sequence of the Lac Operator, Proc. Natl. Acad. Sci. USA 70, 3581-3584 (1973).
* Maxam AM, Tizard R, Skryabin KG, Gilbert W, Promotor region for yeast 5S ribosomal RNA, Nature. 1977 Jun 16;267(5612):643-5

ee also

* Walter Gilbert
* Fred Sanger