Reverse tolerance

Reverse tolerance

Reverse tolerance is the phenomenon of a reversal of the side-effects from a drug, or the reduction of insensitivity caused after drug tolerance has been established. Typically this involves the use of an additional medication, or abstinence from a drug for a period of time, known as a drug holiday. Such drugs include amphetamines, or SSRIs. [cite journal | author = Leith N, Kuczenski R | title = Chronic amphetamine: tolerance and reverse tolerance reflect different behavioral actions of the drug. | journal = Pharmacol Biochem Behav | volume = 15 | issue = 3 | pages = 399–404 | year = 1981 | pmid = 7291243 | doi = 10.1016/0091-3057(81)90269-0] [cite journal | author = Chaudhry I, Turkanis S, Karler R | title = Characteristics of "reverse tolerance" to amphetamine-induced locomotor stimulation in mice. | journal = Neuropharmacology | volume = 27 | issue = 8 | pages = 777–81 | year = 1988 | pmid = 3216957 | doi = 10.1016/0028-3908(88)90091-3] As a result, regular users commonly experience a quick decrease of unwanted side effects, without an equivalent loss of its stimulant properties. Notably, the sensitization is induced more quickly, and persists far longer than withdrawal-related effects, suggesting a phenomenon more complex than a simple tolerance-induced withdrawal syndrome.

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