Epimorphin

Epimorphin

A multifunctional membrane protein with dual topology. Its C terminus is membrane anchored. When the N terminus is on the cytosolic face it acts as a t-SNARE involved in intracellular vesicle docking and is called Syntaxin-2. When flipped inside out, ie N terminus hangs out on the extracellular surface (by some nonclassical secretion pathway) it acts as a versatile morphogen and is called epimorphin. This membrane protein enjoys the double choice of another form of topological alternatives of being targeted to either apical or basolateral surface of an epithelial cell in a regulated way depending on various contexts. When expressed by mesenchymal cells it can instruct epithelial morphogenesis at epithelial mesenchymal interfaces.


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  • STX2 — Syntaxin 2, also known as STX2, is a human gene.cite web | title = Entrez Gene: STX2 syntaxin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2054| accessdate = ] PBB Summary section title = summary text …   Wikipedia

  • Syntaxin — Syntaxine sind Proteine, die sich in Membranen integrieren und bei der Fusion von Membranen mitwirken. Ein Beispiel sind die SNARE Proteine, die bei der Vesikelfusion eine Rolle spielen. So interagiert Syntaxin 1 (t SNARE) mit SNAP 25 und… …   Deutsch Wikipedia

  • Syntaxine — Transporter Klassifikation TCDB …   Deutsch Wikipedia

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